BRD-K50140147_NVP-TAE684_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K50140147_NVP-TAE684_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ANXA6 annexin A6
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ASRGL1 asparaginase like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CD163 CD163 molecule
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
CLCA2 chloride channel accessory 2
CLEC3B C-type lectin domain family 3, member B
CLGN calmegin
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGBP Fc fragment of IgG binding protein
FOXF1 forkhead box F1
GBP2 guanylate binding protein 2, interferon-inducible
GSTM3 glutathione S-transferase mu 3 (brain)
HOXA5 homeobox A5
HP haptoglobin
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IL1R1 interleukin 1 receptor, type I
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
MFAP5 microfibrillar associated protein 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NPDC1 neural proliferation, differentiation and control, 1
OBSL1 obscurin-like 1
OLFM1 olfactomedin 1
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PLAGL1 pleiomorphic adenoma gene-like 1
PROM1 prominin 1
RABGAP1L RAB GTPase activating protein 1-like
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
S100A10 S100 calcium binding protein A10
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SKAP2 src kinase associated phosphoprotein 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BGN biglycan
CCNB1 cyclin B1
CD83 CD83 molecule
CDC45 cell division cycle 45
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN4 claudin 4
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EAPP E2F-associated phosphoprotein
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
FOSL1 FOS-like antigen 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBEGF heparin-binding EGF-like growth factor
INHBA inhibin, beta A
JAG1 jagged 1
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MED13 mediator complex subunit 13
MMP12 matrix metallopeptidase 12
MXRA7 matrix-remodelling associated 7
NR1D2 nuclear receptor subfamily 1, group D, member 2
NREP neuronal regeneration related protein
ODC1 ornithine decarboxylase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
RANBP1 RAN binding protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RNF144A ring finger protein 144A
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SORBS2 sorbin and SH3 domain containing 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF7 serine/arginine-rich splicing factor 7
THBS2 thrombospondin 2
TLK2 tousled-like kinase 2
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
WASF3 WAS protein family, member 3
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZDHHC6 zinc finger, DHHC-type containing 6