BRD-K50140147_NVP-TAE684_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
C14ORF159 chromosome 14 open reading frame 159
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLDN18 claudin 18
CTSH cathepsin H
DAPK1 death-associated protein kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8H golgin A8 family, member H
HLA-DMA major histocompatibility complex, class II, DM alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IDS iduronate 2-sulfatase
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
JUP junction plakoglobin
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LIMCH1 LIM and calponin homology domains 1
MACF1 microtubule-actin crosslinking factor 1
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MVP major vault protein
N4BP2L1 NEDD4 binding protein 2-like 1
NDRG1 N-myc downstream regulated 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL1A oxysterol binding protein-like 1A
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G16 phospholipase A2, group XVI
PNMA2 paraneoplastic Ma antigen 2
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SFXN3 sideroflexin 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STXBP1 syntaxin binding protein 1
TLE4 transducin-like enhancer of split 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIRC5 baculoviral IAP repeat containing 5
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCR4 chemokine (C-X-C motif) receptor 4
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
ELOVL2 ELOVL fatty acid elongase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GCLM glutamate-cysteine ligase, modifier subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRB14 growth factor receptor-bound protein 14
HMGB2 high mobility group box 2
HSPA14 heat shock 70kDa protein 14
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
KIF4A kinesin family member 4A
KRT15 keratin 15, type I
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MMP9 matrix metallopeptidase 9
NEK2 NIMA-related kinase 2
NES nestin
NID2 nidogen 2 (osteonidogen)
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PBK PDZ binding kinase
PDLIM3 PDZ and LIM domain 3
PFN2 profilin 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PTTG1 pituitary tumor-transforming 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SMAD1 SMAD family member 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)