BRD-K50140147_NVP-TAE684_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA6 annexin A6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASCL1 achaete-scute family bHLH transcription factor 1
BRD2 bromodomain containing 2
BST2 bone marrow stromal cell antigen 2
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRDL1 chordin-like 1
CLEC3B C-type lectin domain family 3, member B
CRABP1 cellular retinoic acid binding protein 1
CST3 cystatin C
EMP3 epithelial membrane protein 3
FAM46A family with sequence similarity 46, member A
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
GPC4 glypican 4
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-E major histocompatibility complex, class I, E
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ISG15 ISG15 ubiquitin-like modifier
KLHL24 kelch-like family member 24
LY75 lymphocyte antigen 75
PDIA5 protein disulfide isomerase family A, member 5
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRAGC Ras-related GTP binding C
SATB1 SATB homeobox 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX4 SRY (sex determining region Y)-box 4
STK26 serine/threonine protein kinase 26
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
YPEL5 yippee-like 5 (Drosophila)
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
CA2 carbonic anhydrase II
CAV2 caveolin 2
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
CLDN7 claudin 7
CPE carboxypeptidase E
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXADR coxsackie virus and adenovirus receptor
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DOCK4 dedicator of cytokinesis 4
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRB7 growth factor receptor-bound protein 7
HELLS helicase, lymphoid-specific
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
LIG1 ligase I, DNA, ATP-dependent
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MRPS16 mitochondrial ribosomal protein S16
MTUS1 microtubule associated tumor suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO1B myosin IB
NCAPG2 non-SMC condensin II complex, subunit G2
NET1 neuroepithelial cell transforming 1
NFE2L3 nuclear factor, erythroid 2-like 3
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PLAU plasminogen activator, urokinase
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STMN1 stathmin 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein