BRD-K50140147_NVP-TAE684_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKAP7 A kinase (PRKA) anchor protein 7
ANXA1 annexin A1
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
DDR1 discoidin domain receptor tyrosine kinase 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ETV1 ets variant 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GPX3 glutathione peroxidase 3
GRAMD1C GRAM domain containing 1C
GSN gelsolin
H1F0 H1 histone family, member 0
HECA headcase homolog (Drosophila)
HIST1H2BG histone cluster 1, H2bg
HOPX HOP homeobox
HOXC6 homeobox C6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGL immunoglobulin lambda locus
IQCG IQ motif containing G
KDM3A lysine (K)-specific demethylase 3A
KRT15 keratin 15, type I
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
MAOB monoamine oxidase B
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEX11A peroxisomal biogenesis factor 11 alpha
PITX1 paired-like homeodomain 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
STX1A syntaxin 1A (brain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
USP6NL USP6 N-terminal like
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ATP10B ATPase, class V, type 10B
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXADR coxsackie virus and adenovirus receptor
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EPHA3 EPH receptor A3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
FST follistatin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL1B interleukin 1, beta
KRT23 keratin 23, type I
MAT2A methionine adenosyltransferase II, alpha
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
PDGFA platelet-derived growth factor alpha polypeptide
PENK proenkephalin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLPI secretory leukocyte peptidase inhibitor
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TXNDC9 thioredoxin domain containing 9
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon