BRD-K50140147_HY-10192_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K50140147_HY-10192_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACB acetyl-CoA carboxylase beta
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
CBR3 carbonyl reductase 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COCH cochlin
CPA3 carboxypeptidase A3 (mast cell)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSF cathepsin F
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DPT dermatopontin
EMP2 epithelial membrane protein 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
HIST1H2BK histone cluster 1, H2bk
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IRS2 insulin receptor substrate 2
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LEPR leptin receptor
LITAF lipopolysaccharide-induced TNF factor
LMOD1 leiomodin 1 (smooth muscle)
LPL lipoprotein lipase
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MMP12 matrix metallopeptidase 12
MT1F metallothionein 1F
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM1 PDZ and LIM domain 1
PDZRN3 PDZ domain containing ring finger 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBM47 RNA binding motif protein 47
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGS2 regulator of G-protein signaling 2
S100A9 S100 calcium binding protein A9
SATB2 SATB homeobox 2
SELENBP1 selenium binding protein 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SESN1 sestrin 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYBU syntabulin (syntaxin-interacting)
SYNM synemin, intermediate filament protein
TMOD1 tropomodulin 1
TOB1 transducer of ERBB2, 1
TSC22D1 TSC22 domain family, member 1
TSPAN7 tetraspanin 7
TUBA4A tubulin, alpha 4a
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA6 annexin A6
ARF4 ADP-ribosylation factor 4
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
CBX1 chromobox homolog 1
CDC42 cell division cycle 42
CKAP4 cytoskeleton-associated protein 4
CNN3 calponin 3, acidic
COTL1 coactosin-like F-actin binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DYNLL1 dynein, light chain, LC8-type 1
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB5 integrin, beta 5
KANK1 KN motif and ankyrin repeat domains 1
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRRC59 leucine rich repeat containing 59
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL2 myelin protein zero-like 2
MTCL1 microtubule crosslinking factor 1
MYH10 myosin, heavy chain 10, non-muscle
MYO10 myosin X
NAV3 neuron navigator 3
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
NREP neuronal regeneration related protein
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PRSS23 protease, serine, 23
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS4 regulator of G-protein signaling 4
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A4 S100 calcium binding protein A4
SEC61G Sec61 gamma subunit
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATS2L spermatogenesis associated, serine-rich 2-like
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TPM1 tropomyosin 1 (alpha)
TRIM22 tripartite motif containing 22
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB6 tubulin, beta 6 class V
WWTR1 WW domain containing transcription regulator 1