BRD-K50140147_HY-10192_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K50140147_HY-10192_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRL4 adhesion G protein-coupled receptor L4
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CPE carboxypeptidase E
CREM cAMP responsive element modulator
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DDR2 discoidin domain receptor tyrosine kinase 2
EPAS1 endothelial PAS domain protein 1
FXYD6 FXYD domain containing ion transport regulator 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GREM1 gremlin 1, DAN family BMP antagonist
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
KRT6B keratin 6B, type II
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4B phosphodiesterase 4B, cAMP-specific
PGF placental growth factor
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RGS5 regulator of G-protein signaling 5
SFRP1 secreted frizzled-related protein 1
SRGN serglycin
SSPN sarcospan
STC1 stanniocalcin 1
TCF4 transcription factor 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1
XYLT1 xylosyltransferase I
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
BLCAP bladder cancer associated protein
CCNA2 cyclin A2
CCND1 cyclin D1
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
COTL1 coactosin-like F-actin binding protein 1
CTSH cathepsin H
CYR61 cysteine-rich, angiogenic inducer, 61
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP14 dual specificity phosphatase 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM216A family with sequence similarity 216, member A
FOSL1 FOS-like antigen 1
GRSF1 G-rich RNA sequence binding factor 1
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNB1 karyopherin (importin) beta 1
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MKI67 marker of proliferation Ki-67
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NOLC1 nucleolar and coiled-body phosphoprotein 1
P3H2 prolyl 3-hydroxylase 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
PUS7 pseudouridylate synthase 7 (putative)
RHOBTB3 Rho-related BTB domain containing 3
RRP1B ribosomal RNA processing 1B
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SET SET nuclear proto-oncogene
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit