BRD-K50000283_PHA-767491_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K50000283_PHA-767491_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BICC1 BicC family RNA binding protein 1
C3 complement component 3
COL9A3 collagen, type IX, alpha 3
COPA coatomer protein complex, subunit alpha
CPVL carboxypeptidase, vitellogenic-like
CYBA cytochrome b-245, alpha polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
KAZN kazrin, periplakin interacting protein
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LEF1 lymphoid enhancer-binding factor 1
LEPR leptin receptor
LGALS4 lectin, galactoside-binding, soluble, 4
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MLXIP MLX interacting protein
MYO5C myosin VC
MYRF myelin regulatory factor
NPAS2 neuronal PAS domain protein 2
OGN osteoglycin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDIA5 protein disulfide isomerase family A, member 5
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
PNMAL1 paraneoplastic Ma antigen family-like 1
PRNP prion protein
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB4A RAB4A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
SRSF6 serine/arginine-rich splicing factor 6
TMEM50B transmembrane protein 50B
TPD52 tumor protein D52
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
APOD apolipoprotein D
AQP9 aquaporin 9
ATF5 activating transcription factor 5
C3ORF14 chromosome 3 open reading frame 14
CAB39 calcium binding protein 39
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CLC Charcot-Leyden crystal galectin
COL5A2 collagen, type V, alpha 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST1 cystatin SN
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXOSC4 exosome component 4
GATA3 GATA binding protein 3
GNAS GNAS complex locus
LMO3 LIM domain only 3 (rhombotin-like 2)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYO6 myosin VI
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
OBSL1 obscurin-like 1
PENK proenkephalin
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SOX11 SRY (sex determining region Y)-box 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB16 zinc finger and BTB domain containing 16
ZNF395 zinc finger protein 395