BRD-K49945136_GR 113808_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K49945136_GR 113808_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AIM1 absent in melanoma 1
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
BLNK B-cell linker
CD99 CD99 molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COLEC12 collectin sub-family member 12
CTSZ cathepsin Z
CYBB cytochrome b-245, beta polypeptide
DPP4 dipeptidyl-peptidase 4
E2F2 E2F transcription factor 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FZD2 frizzled class receptor 2
GCLC glutamate-cysteine ligase, catalytic subunit
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KRT15 keratin 15, type I
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MUC4 mucin 4, cell surface associated
MYO6 myosin VI
NEFH neurofilament, heavy polypeptide
NPEPL1 aminopeptidase-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
PPAP2B phosphatidic acid phosphatase type 2B
PTPRE protein tyrosine phosphatase, receptor type, E
RGCC regulator of cell cycle
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
TCF4 transcription factor 4
TMEM110 transmembrane protein 110
TMEM35 transmembrane protein 35
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
C5ORF30 chromosome 5 open reading frame 30
CAB39 calcium binding protein 39
CELF2 CUGBP, Elav-like family member 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FGF13 fibroblast growth factor 13
FRZB frizzled-related protein
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
KLF6 Kruppel-like factor 6
LAPTM4B lysosomal protein transmembrane 4 beta
MAP7 microtubule-associated protein 7
MT1F metallothionein 1F
PLAT plasminogen activator, tissue
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RBP1 retinol binding protein 1, cellular
RPS11 ribosomal protein S11
SGCE sarcoglycan, epsilon
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
THBS1 thrombospondin 1
TSPYL5 TSPY-like 5
TYRP1 tyrosinase-related protein 1