BRD-K49865102_PD-0325901_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

344 genes differentially expressed following the BRD-K49865102_PD-0325901_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOLD1 apolipoprotein L domain containing 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1S complement component 1, s subcomponent
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC3 chloride intracellular channel 3
CLU clusterin
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CRYAB crystallin, alpha B
CTSA cathepsin A
CUX1 cut-like homeobox 1
CXCL2 chemokine (C-X-C motif) ligand 2
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DES desmin
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EHD3 EH-domain containing 3
EPAS1 endothelial PAS domain protein 1
FADS3 fatty acid desaturase 3
FAM114A1 family with sequence similarity 114, member A1
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FBN2 fibrillin 2
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC1 glypican 1
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IL32 interleukin 32
ITGAV integrin, alpha V
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
KIF2C kinesin family member 2C
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LPIN1 lipin 1
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP19 matrix metallopeptidase 19
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOV nephroblastoma overexpressed
NPIPB3 nuclear pore complex interacting protein family, member B3
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OLFM1 olfactomedin 1
OLFML2A olfactomedin-like 2A
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFD platelet derived growth factor D
PDLIM1 PDZ and LIM domain 1
PEG10 paternally expressed 10
PELI2 pellino E3 ubiquitin protein ligase family member 2
PEX11A peroxisomal biogenesis factor 11 alpha
PHACTR2 phosphatase and actin regulator 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNRC1 proline-rich nuclear receptor coactivator 1
PON2 paraoxonase 2
PPAP2A phosphatidic acid phosphatase type 2A
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
PXDC1 PX domain containing 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RHOQ ras homolog family member Q
RPL31 ribosomal protein L31
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPC surfactant protein C
SFTPD surfactant protein D
SGCE sarcoglycan, epsilon
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIDT2 SID1 transmembrane family, member 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STON1 stonin 1
STXBP2 syntaxin binding protein 2
SYNPO synaptopodin
TCEAL2 transcription elongation factor A (SII)-like 2
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TMEM47 transmembrane protein 47
TNNC1 troponin C type 1 (slow)
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSPAN13 tetraspanin 13
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WBP5 WW domain binding protein 5
WDR7 WD repeat domain 7
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ANO1 anoctamin 1, calcium activated chloride channel
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA6 annexin A6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BCL2 B-cell CLL/lymphoma 2
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDCP1 CUB domain containing protein 1
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CKLF chemokine-like factor
CXCR4 chemokine (C-X-C motif) receptor 4
DBF4 DBF4 zinc finger
DEFB1 defensin, beta 1
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
EVI2B ecotropic viral integration site 2B
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FXYD2 FXYD domain containing ion transport regulator 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HOXB7 homeobox B7
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JMJD6 jumonji domain containing 6
LIG1 ligase I, DNA, ATP-dependent
LMO4 LIM domain only 4
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MREG melanoregulin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO10 myosin X
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCH protein kinase C, eta
PSRC1 proline/serine-rich coiled-coil 1
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPIA ribose 5-phosphate isomerase A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100B S100 calcium binding protein B
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC1 syndecan 1
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein