BRD-K49865102_PD-0325901_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K49865102_PD-0325901_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARID5B AT rich interactive domain 5B (MRF1-like)
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
CLU clusterin
CRYAB crystallin, alpha B
CTSZ cathepsin Z
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBN2 fibrillin 2
FILIP1L filamin A interacting protein 1-like
FOXO1 forkhead box O1
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HSPB8 heat shock 22kDa protein 8
KIF2C kinesin family member 2C
KRT19 keratin 19, type I
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
MFAP5 microfibrillar associated protein 5
MYL9 myosin, light chain 9, regulatory
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OXTR oxytocin receptor
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
SIRT3 sirtuin 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
SSPN sarcospan
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TACC1 transforming, acidic coiled-coil containing protein 1
TPM1 tropomyosin 1 (alpha)
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAST calpastatin
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CHN2 chimerin 2
CPVL carboxypeptidase, vitellogenic-like
CXCL9 chemokine (C-X-C motif) ligand 9
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
ETV1 ets variant 1
FOSL1 FOS-like antigen 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
INTS6 integrator complex subunit 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MLPH melanophilin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO10 myosin X
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
SCEL sciellin
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STX1A syntaxin 1A (brain)
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2