BRD-K49865102_PD-0325901_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

320 genes differentially expressed following the BRD-K49865102_PD-0325901_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AK1 adenylate kinase 1
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
BIRC2 baculoviral IAP repeat containing 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CAPN1 calpain 1, (mu/I) large subunit
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CD69 CD69 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHN1 chimerin 1
CHPT1 choline phosphotransferase 1
CLEC2B C-type lectin domain family 2, member B
COL15A1 collagen, type XV, alpha 1
COPS7A COP9 signalosome subunit 7A
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DIO1 deiodinase, iodothyronine, type I
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP4 dipeptidyl-peptidase 4
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
ECI2 enoyl-CoA delta isomerase 2
EGFL6 EGF-like-domain, multiple 6
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
FAM102A family with sequence similarity 102, member A
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
FXYD2 FXYD domain containing ion transport regulator 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GPER1 G protein-coupled estrogen receptor 1
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEBP1 heme binding protein 1
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXA5 homeobox A5
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP1 inositol polyphosphate-1-phosphatase
KAT6B K(lysine) acetyltransferase 6B
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KYNU kynureninase
LOC100129361
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
LYZ lysozyme
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MUC1 mucin 1, cell surface associated
MX1 MX dynamin-like GTPase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NELL2 NEL-like 2 (chicken)
OBSL1 obscurin-like 1
OSR2 odd-skipped related transciption factor 2
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA1A phospholipase A1 member A
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRKCD protein kinase C, delta
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
RAB29 RAB29, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A4 S100 calcium binding protein A4
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPT9 septin 9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMNDC1 survival motor neuron domain containing 1
SOCS2 suppressor of cytokine signaling 2
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STXBP1 syntaxin binding protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TOX thymocyte selection-associated high mobility group box
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPYL4 TSPY-like 4
TSPYL5 TSPY-like 5
TTN titin
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase
VDAC1 voltage-dependent anion channel 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
ADORA2B adenosine A2b receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANGPT1 angiopoietin 1
ANXA1 annexin A1
ASPN asporin
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
BPHL biphenyl hydrolase-like (serine hydrolase)
C1ORF106 chromosome 1 open reading frame 106
CCND2 cyclin D2
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD9 CD9 molecule
CDA cytidine deaminase
CDC20 cell division cycle 20
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
COL10A1 collagen, type X, alpha 1
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
COTL1 coactosin-like F-actin binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPYD dihydropyrimidine dehydrogenase
DSE dermatan sulfate epimerase
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM63A family with sequence similarity 63, member A
FBXL12 F-box and leucine-rich repeat protein 12
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FST follistatin
FSTL1 follistatin-like 1
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GOLM1 golgi membrane protein 1
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HAL histidine ammonia-lyase
HAUS2 HAUS augmin-like complex, subunit 2
HBEGF heparin-binding EGF-like growth factor
HMGB3 high mobility group box 3
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSBP1 heat shock factor binding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLK10 kallikrein-related peptidase 10
KRT20 keratin 20, type I
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LPAR6 lysophosphatidic acid receptor 6
LRRC15 leucine rich repeat containing 15
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM7 minichromosome maintenance complex component 7
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MMP12 matrix metallopeptidase 12
MN1 meningioma (disrupted in balanced translocation) 1
MREG melanoregulin
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
NBL1 neuroblastoma 1, DAN family BMP antagonist
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NID2 nidogen 2 (osteonidogen)
NLRP2 NLR family, pyrin domain containing 2
NNMT nicotinamide N-methyltransferase
NUP85 nucleoporin 85kDa
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
PIP prolactin-induced protein
PKN2 protein kinase N2
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEK2 pleckstrin 2
PPARG peroxisome proliferator-activated receptor gamma
PRSS2 protease, serine, 2 (trypsin 2)
PRSS23 protease, serine, 23
PRSS3 protease, serine, 3
PTRF polymerase I and transcript release factor
PTX3 pentraxin 3, long
PXMP2 peroxisomal membrane protein 2, 22kDa
PYGL phosphorylase, glycogen, liver
RGCC regulator of cell cycle
RIN2 Ras and Rab interactor 2
RPS21 ribosomal protein S21
S100P S100 calcium binding protein P
SCG5 secretogranin V
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMYD3 SET and MYND domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TCERG1 transcription elongation regulator 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDP2 tyrosyl-DNA phosphodiesterase 2
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNS3 tensin 3
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBE2C ubiquitin-conjugating enzyme E2C
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VGLL4 vestigial-like family member 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF430 zinc finger protein 430