BRD-K49865102_PD-0325901_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-K49865102_PD-0325901_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARMT1 acidic residue methyltransferase 1
ASS1 argininosuccinate synthase 1
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
CAPN1 calpain 1, (mu/I) large subunit
CAPN3 calpain 3, (p94)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CRIP2 cysteine-rich protein 2
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP4 dipeptidyl-peptidase 4
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
FBLN1 fibulin 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GHR growth hormone receptor
GPER1 G protein-coupled estrogen receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST2H2BE histone cluster 2, H2be
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IQCG IQ motif containing G
IRX5 iroquois homeobox 5
ISG15 ISG15 ubiquitin-like modifier
KANK2 KN motif and ankyrin repeat domains 2
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LRRN3 leucine rich repeat neuronal 3
MAOB monoamine oxidase B
MEF2C myocyte enhancer factor 2C
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSRB2 methionine sulfoxide reductase B2
MUC1 mucin 1, cell surface associated
MX1 MX dynamin-like GTPase 1
MYH10 myosin, heavy chain 10, non-muscle
MYO10 myosin X
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
OSR2 odd-skipped related transciption factor 2
PCDH9 protocadherin 9
PDZK1 PDZ domain containing 1
PLIN2 perilipin 2
PMEL premelanosome protein
RHOQ ras homolog family member Q
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SFTPC surfactant protein C
SLC38A1 solute carrier family 38, member 1
SLPI secretory leukocyte peptidase inhibitor
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TCF4 transcription factor 4
TFRC transferrin receptor
TGM2 transglutaminase 2
TMEM47 transmembrane protein 47
TRAK2 trafficking protein, kinesin binding 2
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA8 von Willebrand factor A domain containing 8
WFDC2 WAP four-disulfide core domain 2
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADORA2B adenosine A2b receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ATG3 autophagy related 3
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BEX1 brain expressed, X-linked 1
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD200 CD200 molecule
CFB complement factor B
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CNN3 calponin 3, acidic
COL10A1 collagen, type X, alpha 1
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CRELD2 cysteine-rich with EGF-like domains 2
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCR4 chemokine (C-X-C motif) receptor 4
DICER1 dicer 1, ribonuclease type III
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
EIF3M eukaryotic translation initiation factor 3, subunit M
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM49A family with sequence similarity 49, member A
FAM63A family with sequence similarity 63, member A
FBXO11 F-box protein 11
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR1 fibroblast growth factor receptor 1
FMOD fibromodulin
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GOLM1 golgi membrane protein 1
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IPO13 importin 13
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
LAMP5 lysosomal-associated membrane protein family, member 5
LPAR1 lysophosphatidic acid receptor 1
LPAR6 lysophosphatidic acid receptor 6
LRRC15 leucine rich repeat containing 15
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MT1M metallothionein 1M
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEBL nebulette
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPTX2 neuronal pentraxin II
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
TCERG1 transcription elongation regulator 1
TGFB1 transforming growth factor, beta 1
THAP11 THAP domain containing 11
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM123 transmembrane protein 123
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS3 tensin 3
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF292 zinc finger protein 292
ZNF395 zinc finger protein 395