BRD-K49865102_PD-0325901_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-K49865102_PD-0325901_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CDKN2A cyclin-dependent kinase inhibitor 2A
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DAPK1 death-associated protein kinase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
GBP2 guanylate binding protein 2, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
JUP junction plakoglobin
KAZN kazrin, periplakin interacting protein
LMCD1 LIM and cysteine-rich domains 1
MAOB monoamine oxidase B
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MFAP3L microfibrillar-associated protein 3-like
MN1 meningioma (disrupted in balanced translocation) 1
NAMPT nicotinamide phosphoribosyltransferase
NRN1 neuritin 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SLC39A14 solute carrier family 39 (zinc transporter), member 14
TKTL1 transketolase-like 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPH aspartate beta-hydroxylase
BEX1 brain expressed, X-linked 1
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDCP1 CUB domain containing protein 1
CHGB chromogranin B
COL15A1 collagen, type XV, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CSNK1E casein kinase 1, epsilon
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DCBLD2 discoidin, CUB and LCCL domain containing 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FRMD4B FERM domain containing 4B
FZD10 frizzled class receptor 10
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
ITGA6 integrin, alpha 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MOAP1 modulator of apoptosis 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTHLH parathyroid hormone-like hormone
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB38 RAB38, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A2 S100 calcium binding protein A2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC43A3 solute carrier family 43, member 3
SMAGP small cell adhesion glycoprotein
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TRIB2 tribbles pseudokinase 2
TSPAN5 tetraspanin 5
WWTR1 WW domain containing transcription regulator 1
ZFP36L1 ZFP36 ring finger protein-like 1