BRD-K49865102_PD-0325901_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

469 genes differentially expressed following the BRD-K49865102_PD-0325901_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
APOL1 apolipoprotein L, 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP9A ATPase, class II, type 9A
ATRX alpha thalassemia/mental retardation syndrome X-linked
BBX bobby sox homolog (Drosophila)
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1S complement component 1, s subcomponent
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFD complement factor D (adipsin)
CLDN7 claudin 7
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CTSD cathepsin D
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNASE2 deoxyribonuclease II, lysosomal
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EHD3 EH-domain containing 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP2 epithelial membrane protein 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP3 fatty acid binding protein 3, muscle and heart
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIF2C kinesin family member 2C
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT8 keratin 8, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LRRC16A leucine rich repeat containing 16A
LTB lymphotoxin beta (TNF superfamily, member 3)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDLIM1 PDZ and LIM domain 1
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PHACTR2 phosphatase and actin regulator 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLXNB1 plexin B1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2C phosphatidic acid phosphatase type 2C
PPL periplakin
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRSS8 protease, serine, 8
PTGES prostaglandin E synthase
PTPRF protein tyrosine phosphatase, receptor type, F
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPL31 ribosomal protein L31
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SMA4 glucuronidase, beta pseudogene
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
STXBP2 syntaxin binding protein 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEAL4 transcription elongation factor A (SII)-like 4
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNS1 tensin 1
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
UBE2H ubiquitin-conjugating enzyme E2H
UBXN4 UBX domain protein 4
VAT1 vesicle amine transport 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WBP1L WW domain binding protein 1-like
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZNF91 zinc finger protein 91
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ANO1 anoctamin 1, calcium activated chloride channel
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW1 basic leucine zipper and W2 domains 1
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DOCK4 dedicator of cytokinesis 4
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR2 early growth response 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELP5 elongator acetyltransferase complex subunit 5
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV1 ets variant 1
ETV5 ets variant 5
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FST follistatin
GAL galanin/GMAP prepropeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LAP3 leucine aminopeptidase 3
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
NUP93 nucleoporin 93kDa
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
ORC6 origin recognition complex, subunit 6
PA2G4 proliferation-associated 2G4, 38kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PSMC3IP PSMC3 interacting protein
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
QDPR quinoid dihydropteridine reductase
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFWD3 ring finger and WD repeat domain 3
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SEH1L SEH1-like (S. cerevisiae)
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SHCBP1 SHC SH2-domain binding protein 1
SLBP stem-loop binding protein
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLIT2 slit homolog 2 (Drosophila)
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SOX9 SRY (sex determining region Y)-box 9
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein