BRD-K49865102_PD-0325901_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

415 genes differentially expressed following the BRD-K49865102_PD-0325901_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
APOL1 apolipoprotein L, 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BPIFA1 BPI fold containing family A, member 1
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFD complement factor D (adipsin)
CLIC5 chloride intracellular channel 5
CLU clusterin
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8L2 EPS8-like 2
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
FAM134B family with sequence similarity 134, member B
FAM13B family with sequence similarity 13, member B
FBLN1 fibulin 1
FBLN2 fibulin 2
FGF9 fibroblast growth factor 9
FXYD3 FXYD domain containing ion transport regulator 3
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL18 interleukin 18
IL1B interleukin 1, beta
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
KDM3A lysine (K)-specific demethylase 3A
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
KRT8 keratin 8, type II
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC16A leucine rich repeat containing 16A
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NDRG1 N-myc downstream regulated 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PDZK1IP1 PDZK1 interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PINK1 PTEN induced putative kinase 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLS3 plastin 3
PPL periplakin
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
PTGES prostaglandin E synthase
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RAB40B RAB40B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTSSA serine palmitoyltransferase, small subunit A
STC2 stanniocalcin 2
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TAPBP TAP binding protein (tapasin)
TCEAL4 transcription elongation factor A (SII)-like 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TNXB tenascin XB
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UST uronyl-2-sulfotransferase
VAMP8 vesicle-associated membrane protein 8
VAV3 vav 3 guanine nucleotide exchange factor
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WBP1L WW domain binding protein 1-like
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WISP2 WNT1 inducible signaling pathway protein 2
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW1 basic leucine zipper and W2 domains 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
ELOVL2 ELOVL fatty acid elongase 2
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV1 ets variant 1
ETV5 ets variant 5
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LBR lamin B receptor
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKD3 protein kinase D3
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PTTG1 pituitary tumor-transforming 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPHK1 sphingosine kinase 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TSPAN4 tetraspanin 4
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein