BRD-K49865102_PD-0325901_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K49865102_PD-0325901_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
CAST calpastatin
CRIP1 cysteine-rich protein 1 (intestinal)
CTSH cathepsin H
DCT dopachrome tautomerase
DDIT4 DNA-damage-inducible transcript 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
GAS1 growth arrest-specific 1
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB7 homeobox B7
IDO1 indoleamine 2,3-dioxygenase 1
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
LAMP3 lysosomal-associated membrane protein 3
MAL mal, T-cell differentiation protein
MTUS1 microtubule associated tumor suppressor 1
NEBL nebulette
NREP neuronal regeneration related protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PMEL premelanosome protein
PRAME preferentially expressed antigen in melanoma
PTPRO protein tyrosine phosphatase, receptor type, O
RGS1 regulator of G-protein signaling 1
S100A7 S100 calcium binding protein A7
SCGB2A1 secretoglobin, family 2A, member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
STXBP1 syntaxin binding protein 1
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTA1 actin, alpha 1, skeletal muscle
ADCK3 aarF domain containing kinase 3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BID BH3 interacting domain death agonist
CCND1 cyclin D1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GFAP glial fibrillary acidic protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JUN jun proto-oncogene
KLK5 kallikrein-related peptidase 5
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEB nebulin
NES nestin
NT5E 5'-nucleotidase, ecto (CD73)
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PTN pleiotrophin
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLN sarcolipin
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TLR4 toll-like receptor 4
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNI2 troponin I type 2 (skeletal, fast)
TPM2 tropomyosin 2 (beta)
WEE1 WEE1 G2 checkpoint kinase