BRD-K49865102_PD-0325901_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K49865102_PD-0325901_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ADA adenosine deaminase
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA4 annexin A4
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX6 armadillo repeat containing, X-linked 6
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL2A1 BCL2-related protein A1
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CD14 CD14 molecule
CD300A CD300a molecule
CD47 CD47 molecule
CD58 CD58 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CYB561 cytochrome b561
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
DUSP22 dual specificity phosphatase 22
ELOVL5 ELOVL fatty acid elongase 5
FABP4 fatty acid binding protein 4, adipocyte
FAM8A1 family with sequence similarity 8, member A1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HBD hemoglobin, delta
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFT57 intraflagellar transport 57
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LEPR leptin receptor
LUM lumican
MAGED2 melanoma antigen family D2
MAOB monoamine oxidase B
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OXTR oxytocin receptor
PAWR PRKC, apoptosis, WT1, regulator
PDIA5 protein disulfide isomerase family A, member 5
PENK proenkephalin
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RHOQ ras homolog family member Q
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SORBS2 sorbin and SH3 domain containing 2
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC2 stanniocalcin 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VWA8 von Willebrand factor A domain containing 8
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZMYM2 zinc finger, MYM-type 2
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASF1B anti-silencing function 1B histone chaperone
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPU centromere protein U
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CLTB clathrin, light chain B
COPS7A COP9 signalosome subunit 7A
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUOX2 dual oxidase 2
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
IFRD2 interferon-related developmental regulator 2
IL1R2 interleukin 1 receptor, type II
ITGB1BP1 integrin beta 1 binding protein 1
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF1BP KIF1 binding protein
KRT6B keratin 6B, type II
LIG1 ligase I, DNA, ATP-dependent
LOC283683 uncharacterized LOC283683
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX1 neuronal pentraxin I
NPTX2 neuronal pentraxin II
NUP85 nucleoporin 85kDa
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PLAU plasminogen activator, urokinase
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSCA prostate stem cell antigen
RAD51AP1 RAD51 associated protein 1
RAD9A RAD9 homolog A (S. pombe)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAM transcription factor A, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TLR4 toll-like receptor 4
TMEM194A transmembrane protein 194A
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein