BRD-K49865102_PD-0325901_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K49865102_PD-0325901_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA4 annexin A4
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
CPM carboxypeptidase M
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DHDDS dehydrodolichyl diphosphate synthase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FBLN2 fibulin 2
FRZB frizzled-related protein
H2AFV H2A histone family, member V
HBB hemoglobin, beta
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL32 interleukin 32
INSIG1 insulin induced gene 1
LCN2 lipocalin 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAL mal, T-cell differentiation protein
MMP7 matrix metallopeptidase 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
NRN1 neuritin 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAC8 placenta-specific 8
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN3 reticulon 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPP1 secreted phosphoprotein 1
STOM stomatin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
ADCK3 aarF domain containing kinase 3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND1 cyclin D1
CD81 CD81 molecule
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
COL13A1 collagen, type XIII, alpha 1
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
FAM3C family with sequence similarity 3, member C
FCMR Fc fragment of IgM receptor
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA6 GATA binding protein 6
GPR137B G protein-coupled receptor 137B
GSAP gamma-secretase activating protein
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPCAL1 hippocalcin-like 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
JAG1 jagged 1
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
LIF leukemia inhibitory factor
LIMA1 LIM domain and actin binding 1
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MREG melanoregulin
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
RGS2 regulator of G-protein signaling 2
SDC4 syndecan 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIX2 SIX homeobox 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC38A1 solute carrier family 38, member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
VEGFC vascular endothelial growth factor C