BRD-K49865102_PD-0325901_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

312 genes differentially expressed following the BRD-K49865102_PD-0325901_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BIRC3 baculoviral IAP repeat containing 3
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
C19ORF66 chromosome 19 open reading frame 66
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C9ORF3 chromosome 9 open reading frame 3
CA12 carbonic anhydrase XII
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC92 coiled-coil domain containing 92
CD47 CD47 molecule
CD58 CD58 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CYB5R1 cytochrome b5 reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSC3 desmocollin 3
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
FAM134B family with sequence similarity 134, member B
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GPC1 glypican 1
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HEG1 heart development protein with EGF-like domains 1
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IL15 interleukin 15
IL32 interleukin 32
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMB2 laminin, beta 2 (laminin S)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LMOD1 leiomodin 1 (smooth muscle)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6D lymphocyte antigen 6 complex, locus D
MATN2 matrilin 2
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
MYL9 myosin, light chain 9, regulatory
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OPTN optineurin
OSR2 odd-skipped related transciption factor 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLK2 polo-like kinase 2
PLXNB2 plexin B2
PPAP2A phosphatidic acid phosphatase type 2A
PPIC peptidylprolyl isomerase C (cyclophilin C)
QPRT quinolinate phosphoribosyltransferase
RHOB ras homolog family member B
RIOK3 RIO kinase 3
S100A8 S100 calcium binding protein A8
SCARB1 scavenger receptor class B, member 1
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SORBS2 sorbin and SH3 domain containing 2
SPON2 spondin 2, extracellular matrix protein
SSBP2 single-stranded DNA binding protein 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNC syncoilin, intermediate filament protein
SYNPO synaptopodin
TAGLN transgelin
TCEAL4 transcription elongation factor A (SII)-like 4
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPST2 tyrosylprotein sulfotransferase 2
TRAM2 translocation associated membrane protein 2
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
UBA7 ubiquitin-like modifier activating enzyme 7
VAV3 vav 3 guanine nucleotide exchange factor
VLDLR very low density lipoprotein receptor
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AREG amphiregulin
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
DAZAP1 DAZ associated protein 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EGR1 early growth response 1
EGR2 early growth response 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ILF2 interleukin enhancer binding factor 2
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LPAR1 lysophosphatidic acid receptor 1
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NAV3 neuron navigator 3
NET1 neuroepithelial cell transforming 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NT5E 5'-nucleotidase, ecto (CD73)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNX10 sorting nexin 10
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SRPK1 SRSF protein kinase 1
SRPX sushi-repeat containing protein, X-linked
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMELESS timeless circadian clock
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein