BRD-K49865102_PD-0325901_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

377 genes differentially expressed following the BRD-K49865102_PD-0325901_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK AHNAK nucleoprotein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMACR alpha-methylacyl-CoA racemase
ANXA2P2 annexin A2 pseudogene 2
ANXA4 annexin A4
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BPHL biphenyl hydrolase-like (serine hydrolase)
BPIFA1 BPI fold containing family A, member 1
C5 complement component 5
C9ORF16 chromosome 9 open reading frame 16
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CBR1 carbonyl reductase 1
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFD complement factor D (adipsin)
CHGB chromogranin B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN3 claudin 3
CREB1 cAMP responsive element binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSTB cystatin B (stefin B)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSD cathepsin D
CXADR coxsackie virus and adenovirus receptor
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCTN1 dynactin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DRAM1 DNA-damage regulated autophagy modulator 1
DSTN destrin (actin depolymerizing factor)
DUSP3 dual specificity phosphatase 3
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FCGBP Fc fragment of IgG binding protein
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD3 FXYD domain containing ion transport regulator 3
GALC galactosylceramidase
GDE1 glycerophosphodiester phosphodiesterase 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
HBB hemoglobin, beta
HDAC6 histone deacetylase 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IL6R interleukin 6 receptor
INHBB inhibin, beta B
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
JUP junction plakoglobin
KDM5D lysine (K)-specific demethylase 5D
KIAA0232 KIAA0232
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
LRRC16A leucine rich repeat containing 16A
LXN latexin
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NLGN4X neuroligin 4, X-linked
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSG1 neuron specific gene family member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAX8 paired box 8
PBX1 pre-B-cell leukemia homeobox 1
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PLCB4 phospholipase C, beta 4
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
PRSS23 protease, serine, 23
PSAP prosaposin
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM47 RNA binding motif protein 47
REEP5 receptor accessory protein 5
REG1A regenerating islet-derived 1 alpha
RFK riboflavin kinase
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
S100A14 S100 calcium binding protein A14
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SQLE squalene epoxidase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
SYBU syntabulin (syntaxin-interacting)
TAC1 tachykinin, precursor 1
TACSTD2 tumor-associated calcium signal transducer 2
TAPBP TAP binding protein (tapasin)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCTA T-cell leukemia translocation altered
TCTN1 tectonic family member 1
THSD7A thrombospondin, type I, domain containing 7A
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TRAC T cell receptor alpha constant
TRIM29 tripartite motif containing 29
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VWF von Willebrand factor
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF274 zinc finger protein 274
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AIM2 absent in melanoma 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA1 annexin A1
ANXA10 annexin A10
APOD apolipoprotein D
APOE apolipoprotein E
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
CALML3 calmodulin-like 3
CAPRIN2 caprin family member 2
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCNA2 cyclin A2
CDA cytidine deaminase
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FBP1 fructose-1,6-bisphosphatase 1
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FST follistatin
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
GNLY granulysin
GPER1 G protein-coupled estrogen receptor 1
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HAT1 histone acetyltransferase 1
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB2 high mobility group box 2
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HYOU1 hypoxia up-regulated 1
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IL13RA2 interleukin 13 receptor, alpha 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD5 potassium channel tetramerization domain containing 5
KIF14 kinesin family member 14
LGALS2 lectin, galactoside-binding, soluble, 2
LMO4 LIM domain only 4
LY6E lymphocyte antigen 6 complex, locus E
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTA1 metastasis associated 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OPHN1 oligophrenin 1
P3H2 prolyl 3-hydroxylase 2
PAX6 paired box 6
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPAT phosphoribosyl pyrophosphate amidotransferase
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRSS3 protease, serine, 3
PSRC1 proline/serine-rich coiled-coil 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTX3 pentraxin 3, long
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
SATB2 SATB homeobox 2
SCD5 stearoyl-CoA desaturase 5
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMC1A structural maintenance of chromosomes 1A
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SRRM2 serine/arginine repetitive matrix 2
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TESC tescalcin
TEX30 testis expressed 30
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TSPAN5 tetraspanin 5
UBN1 ubinuclein 1
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1
ZNF395 zinc finger protein 395
ZWINT ZW10 interacting kinetochore protein