BRD-K49865102_PD-0325901_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

412 genes differentially expressed following the BRD-K49865102_PD-0325901_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACTC1 actin, alpha, cardiac muscle 1
ADRB2 adrenoceptor beta 2, surface
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX15B arachidonate 15-lipoxygenase, type B
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANOS1 anosmin 1
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
BPHL biphenyl hydrolase-like (serine hydrolase)
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C1ORF106 chromosome 1 open reading frame 106
C8ORF4 chromosome 8 open reading frame 4
C9ORF3 chromosome 9 open reading frame 3
CALB1 calbindin 1, 28kDa
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COCH cochlin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CRYM crystallin, mu
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAXX death-domain associated protein
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EFNA1 ephrin-A1
EGF epidermal growth factor
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GANAB glucosidase, alpha; neutral AB
GBP1 guanylate binding protein 1, interferon-inducible
GP2 glycoprotein 2 (zymogen granule membrane)
GPC1 glypican 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IGSF3 immunoglobulin superfamily, member 3
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
KLF6 Kruppel-like factor 6
KLK11 kallikrein-related peptidase 11
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
LAMA4 laminin, alpha 4
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALT1 MALT1 paracaspase
MDK midkine (neurite growth-promoting factor 2)
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MSRB2 methionine sulfoxide reductase B2
MUC1 mucin 1, cell surface associated
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NEB nebulin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NQO2 NAD(P)H dehydrogenase, quinone 2
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPTN optineurin
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PDGFRL platelet-derived growth factor receptor-like
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PIR pirin (iron-binding nuclear protein)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G16 phospholipase A2, group XVI
PLBD1 phospholipase B domain containing 1
PLLP plasmolipin
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR1 phospholipid scramblase 1
PON2 paraoxonase 2
PRSS21 protease, serine, 21 (testisin)
PRUNE2 prune homolog 2 (Drosophila)
RAB25 RAB25, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RSAD2 radical S-adenosyl methionine domain containing 2
RTN1 reticulon 1
RYBP RING1 and YY1 binding protein
S100A11 S100 calcium binding protein A11
SAMD4A sterile alpha motif domain containing 4A
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SOX2 SRY (sex determining region Y)-box 2
SPRED2 sprouty-related, EVH1 domain containing 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK38L serine/threonine kinase 38 like
STMN2 stathmin 2
STOM stomatin
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TARP TCR gamma alternate reading frame protein
TGFBR3 transforming growth factor, beta receptor III
TKT transketolase
TMOD1 tropomodulin 1
TMPRSS2 transmembrane protease, serine 2
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP18 ubiquitin specific peptidase 18
VDAC1 voltage-dependent anion channel 1
VLDLR very low density lipoprotein receptor
VSNL1 visinin-like 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YME1L1 YME1-like 1 ATPase

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACOX2 acyl-CoA oxidase 2, branched chain
ADORA2B adenosine A2b receptor
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ARHGAP29 Rho GTPase activating protein 29
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C7 complement component 7
CA2 carbonic anhydrase II
CCND1 cyclin D1
CCND2 cyclin D2
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFD complement factor D (adipsin)
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC3B C-type lectin domain family 3, member B
COL13A1 collagen, type XIII, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC11 collectin sub-family member 11
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP3 dual specificity phosphatase 3
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENG endoglin
EREG epiregulin
EVI2A ecotropic viral integration site 2A
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FJX1 four jointed box 1 (Drosophila)
FKBP1A FK506 binding protein 1A, 12kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FMOD fibromodulin
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
FYB FYN binding protein
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAL galanin/GMAP prepropeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GOLM1 golgi membrane protein 1
GSAP gamma-secretase activating protein
HIST1H4C histone cluster 1, H4c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA2 high mobility group AT-hook 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
INSM1 insulinoma-associated 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KCTD12 potassium channel tetramerization domain containing 12
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT81 keratin 81, type II
LAPTM5 lysosomal protein transmembrane 5
LDB2 LIM domain binding 2
LGALS2 lectin, galactoside-binding, soluble, 2
LINC00341 long intergenic non-protein coding RNA 341
LPAR1 lysophosphatidic acid receptor 1
LY75 lymphocyte antigen 75
MAB21L2 mab-21-like 2 (C. elegans)
MAPK13 mitogen-activated protein kinase 13
MBP myelin basic protein
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MET MET proto-oncogene, receptor tyrosine kinase
MMP9 matrix metallopeptidase 9
MTF2 metal response element binding transcription factor 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV3 neuron navigator 3
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX1 neuronal pentraxin I
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PAEP progestagen-associated endometrial protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP2 plakophilin 2
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS2 protease, serine, 2 (trypsin 2)
PSPH phosphoserine phosphatase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGCC regulator of cell cycle
RPIA ribose 5-phosphate isomerase A
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SORD sorbitol dehydrogenase
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP11 THAP domain containing 11
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TSPAN4 tetraspanin 4
TSPAN5 tetraspanin 5
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VCAN versican
VNN1 vanin 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
XPO7 exportin 7