BRD-K49865102_PD-0325901_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K49865102_PD-0325901_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC3 chloride intracellular channel 3
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CRISP3 cysteine-rich secretory protein 3
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST3 cystatin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EDN1 endothelin 1
EGF epidermal growth factor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GBP1 guanylate binding protein 1, interferon-inducible
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GREM1 gremlin 1, DAN family BMP antagonist
H1FX H1 histone family, member X
HBB hemoglobin, beta
HEPH hephaestin
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IL13RA1 interleukin 13 receptor, alpha 1
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
INHBA inhibin, beta A
IQGAP1 IQ motif containing GTPase activating protein 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
LOX lysyl oxidase
MAP1B microtubule-associated protein 1B
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MMP12 matrix metallopeptidase 12
MPP1 membrane protein, palmitoylated 1, 55kDa
MX1 MX dynamin-like GTPase 1
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OXTR oxytocin receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PENK proenkephalin
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLCB4 phospholipase C, beta 4
PLSCR1 phospholipid scramblase 1
PON2 paraoxonase 2
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAB2A RAB2A, member RAS oncogene family
RBKS ribokinase
RHCG Rh family, C glycoprotein
RPS4Y1 ribosomal protein S4, Y-linked 1
RSAD2 radical S-adenosyl methionine domain containing 2
S100A10 S100 calcium binding protein A10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SOD2 superoxide dismutase 2, mitochondrial
SP100 SP100 nuclear antigen
SRRM2 serine/arginine repetitive matrix 2
STAT1 signal transducer and activator of transcription 1, 91kDa
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
THBS1 thrombospondin 1
TM7SF2 transmembrane 7 superfamily member 2
TNF tumor necrosis factor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TUBB2A tubulin, beta 2A class IIa
USP6NL USP6 N-terminal like
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XAF1 XIAP associated factor 1
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABLIM1 actin binding LIM protein 1
ACD adrenocortical dysplasia homolog (mouse)
ADGRA3 adhesion G protein-coupled receptor A3
ADGRL2 adhesion G protein-coupled receptor L2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
C7 complement component 7
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CLEC2B C-type lectin domain family 2, member B
CLEC3B C-type lectin domain family 3, member B
CLGN calmegin
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
CRABP1 cellular retinoic acid binding protein 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTBP2 C-terminal binding protein 2
CYTL1 cytokine-like 1
DCHS1 dachsous cadherin-related 1
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
EEF2 eukaryotic translation elongation factor 2
EGR1 early growth response 1
EGR2 early growth response 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENG endoglin
EPAS1 endothelial PAS domain protein 1
EPHA3 EPH receptor A3
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAM3C family with sequence similarity 3, member C
FDX1 ferredoxin 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GUSBP11 glucuronidase, beta pseudogene 11
HES1 hes family bHLH transcription factor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IPO13 importin 13
JAM3 junctional adhesion molecule 3
LAPTM4B lysosomal protein transmembrane 4 beta
LITAF lipopolysaccharide-induced TNF factor
LPAR2 lysophosphatidic acid receptor 2
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
MMD monocyte to macrophage differentiation-associated
MRPL19 mitochondrial ribosomal protein L19
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NRP1 neuropilin 1
PAMR1 peptidase domain containing associated with muscle regeneration 1
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PFN2 profilin 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLTP phospholipid transfer protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCDBP protein kinase C, delta binding protein
PRKCH protein kinase C, eta
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTN2 reticulon 2
SCG5 secretogranin V
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNX7 sorting nexin 7
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STAB1 stabilin 1
STC1 stanniocalcin 1
SYNM synemin, intermediate filament protein
YBX3 Y box binding protein 3
ZNF395 zinc finger protein 395
ZNF589 zinc finger protein 589