BRD-K49865102_PD-0325901_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K49865102_PD-0325901_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
C1ORF116 chromosome 1 open reading frame 116
C2 complement component 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CFB complement factor B
CLDN7 claudin 7
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
CTSO cathepsin O
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM13A family with sequence similarity 13, member A
FBLN1 fibulin 1
FOLR1 folate receptor 1 (adult)
FZD5 frizzled class receptor 5
GJA1 gap junction protein, alpha 1, 43kDa
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX2 glutathione peroxidase 2
GSN gelsolin
HECA headcase homolog (Drosophila)
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HSPB8 heat shock 22kDa protein 8
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT4 keratin 4, type II
LBH limb bud and heart development
MAOA monoamine oxidase A
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MID1 midline 1
MME membrane metallo-endopeptidase
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
NR2F6 nuclear receptor subfamily 2, group F, member 6
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PSCA prostate stem cell antigen
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM47 RNA binding motif protein 47
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPARCL1 SPARC-like 1 (hevin)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TCF4 transcription factor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
AREG amphiregulin
AXL AXL receptor tyrosine kinase
CA2 carbonic anhydrase II
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CLTB clathrin, light chain B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MMP9 matrix metallopeptidase 9
MYBPC1 myosin binding protein C, slow type
NME4 NME/NM23 nucleoside diphosphate kinase 4
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRSS2 protease, serine, 2 (trypsin 2)
RFC5 replication factor C (activator 1) 5, 36.5kDa
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SVIL supervillin
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TRBC1 T cell receptor beta constant 1
TYMS thymidylate synthetase
VNN1 vanin 1
ZYX zyxin