BRD-K49865102_PD-0325901_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K49865102_PD-0325901_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDOB aldolase B, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOC1 apolipoprotein C-I
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
C3ORF14 chromosome 3 open reading frame 14
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFD complement factor D (adipsin)
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CXCL14 chemokine (C-X-C motif) ligand 14
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EFNA1 ephrin-A1
FABP1 fatty acid binding protein 1, liver
FBP1 fructose-1,6-bisphosphatase 1
FGFR2 fibroblast growth factor receptor 2
GJA1 gap junction protein, alpha 1, 43kDa
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
IFI30 interferon, gamma-inducible protein 30
IGL immunoglobulin lambda locus
IPO13 importin 13
IRF8 interferon regulatory factor 8
LIMCH1 LIM and calponin homology domains 1
LYZ lysozyme
MAMLD1 mastermind-like domain containing 1
MATN2 matrilin 2
MECOM MDS1 and EVI1 complex locus
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MPZL2 myelin protein zero-like 2
MSLN mesothelin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
ORM1 orosomucoid 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PIR pirin (iron-binding nuclear protein)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RAB31 RAB31, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RHOBTB1 Rho-related BTB domain containing 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOCS2 suppressor of cytokine signaling 2
SULF1 sulfatase 1
TFF1 trefoil factor 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
YPEL5 yippee-like 5 (Drosophila)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
APP amyloid beta (A4) precursor protein
AREG amphiregulin
BTG3 BTG family, member 3
CANX calnexin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MED1 mediator complex subunit 1
NPTX2 neuronal pentraxin II
PAWR PRKC, apoptosis, WT1, regulator
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PPIF peptidylprolyl isomerase F
PRSS3 protease, serine, 3
SCG2 secretogranin II
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
TM4SF1 transmembrane 4 L six family member 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon