BRD-K49657628_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K49657628_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACVR1 activin A receptor, type I
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
ANXA5 annexin A5
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
C1ORF106 chromosome 1 open reading frame 106
C3ORF52 chromosome 3 open reading frame 52
CBR3 carbonyl reductase 3
CD58 CD58 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHIC2 cysteine-rich hydrophobic domain 2
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTSK cathepsin K
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GPC1 glypican 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IL11 interleukin 11
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM6B lysine (K)-specific demethylase 6B
KIAA0355 KIAA0355
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLHL21 kelch-like family member 21
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MALL mal, T-cell differentiation protein-like
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K3 mitogen-activated protein kinase kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
NDEL1 nudE neurodevelopment protein 1-like 1
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
PEA15 phosphoprotein enriched in astrocytes 15
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
POPDC3 popeye domain containing 3
PPARD peroxisome proliferator-activated receptor delta
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
RBMS1 RNA binding motif, single stranded interacting protein 1
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RND1 Rho family GTPase 1
RNF19B ring finger protein 19B
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SPAG9 sperm associated antigen 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
SRGN serglycin
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
THBD thrombomodulin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM4 tropomyosin 4
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANXA4 annexin A4
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
C14ORF132 chromosome 14 open reading frame 132
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
COPA coatomer protein complex, subunit alpha
CP ceruloplasmin (ferroxidase)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ENO2 enolase 2 (gamma, neuronal)
ERBB3 erb-b2 receptor tyrosine kinase 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
HOXA10 homeobox A10
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LOX lysyl oxidase
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOB monoamine oxidase B
MEIS1 Meis homeobox 1
METTL17 methyltransferase like 17
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYRF myelin regulatory factor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NREP neuronal regeneration related protein
OBSL1 obscurin-like 1
PEG10 paternally expressed 10
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSRC1 proline/serine-rich coiled-coil 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RGS2 regulator of G-protein signaling 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM106C transmembrane protein 106C
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
VTCN1 V-set domain containing T cell activation inhibitor 1
ZMYM3 zinc finger, MYM-type 3