BRD-K49630153_NCGC00183226-01_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K49630153_NCGC00183226-01_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
COL11A1 collagen, type XI, alpha 1
DDIT4 DNA-damage-inducible transcript 4
ELANE elastase, neutrophil expressed
EREG epiregulin
FAM171A1 family with sequence similarity 171, member A1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
JAG1 jagged 1
KLHL21 kelch-like family member 21
LAMC2 laminin, gamma 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
NMU neuromedin U
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PRR7 proline rich 7 (synaptic)
PTN pleiotrophin
RAP1GAP RAP1 GTPase activating protein
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SERINC5 serine incorporator 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPRY2 sprouty homolog 2 (Drosophila)
TPM2 tropomyosin 2 (beta)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
ZIC1 Zic family member 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C1GALT1C1 C1GALT1-specific chaperone 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CD200 CD200 molecule
CD47 CD47 molecule
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CGRRF1 cell growth regulator with ring finger domain 1
COX17 COX17 cytochrome c oxidase copper chaperone
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EAPP E2F-associated phosphoprotein
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FEN1 flap structure-specific endonuclease 1
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLO1 glyoxalase I
GLS glutaminase
GSTA1 glutathione S-transferase alpha 1
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LMBRD1 LMBR1 domain containing 1
MANSC1 MANSC domain containing 1
MAP7 microtubule-associated protein 7
MED21 mediator complex subunit 21
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGRMC2 progesterone receptor membrane component 2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNASE4 ribonuclease, RNase A family, 4
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SELT selenoprotein T
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPDEF SAM pointed domain containing ETS transcription factor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM106C transmembrane protein 106C
TMEM14A transmembrane protein 14A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRAPPC4 trafficking protein particle complex 4
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGCG UDP-glucose ceramide glucosyltransferase
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein