BRD-K49553303_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K49553303_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
C14ORF1 chromosome 14 open reading frame 1
CETN2 centrin, EF-hand protein, 2
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDPS farnesyl diphosphate synthase
GLRX glutaredoxin (thioltransferase)
H1F0 H1 histone family, member 0
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LXN latexin
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OAT ornithine aminotransferase
PDLIM5 PDZ and LIM domain 5
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP1 secreted frizzled-related protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SORD sorbitol dehydrogenase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ASCL1 achaete-scute family bHLH transcription factor 1
BMP2 bone morphogenetic protein 2
CCL4 chemokine (C-C motif) ligand 4
CHEK1 checkpoint kinase 1
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
INA internexin neuronal intermediate filament protein, alpha
KRT20 keratin 20, type I
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
NCAM1 neural cell adhesion molecule 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
SNX7 sorting nexin 7
TOX3 TOX high mobility group box family member 3