BRD-K49468759_KIN001-266_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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68 genes differentially expressed following the BRD-K49468759_KIN001-266_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
BAX BCL2-associated X protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COX17 COX17 cytochrome c oxidase copper chaperone
CSTA cystatin A (stefin A)
CYB561 cytochrome b561
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DYNLT1 dynein, light chain, Tctex-type 1
ELOVL6 ELOVL fatty acid elongase 6
FBXO11 F-box protein 11
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPM6B glycoprotein M6B
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT13 keratin 13, type I
KRT19 keratin 19, type I
L1TD1 LINE-1 type transposase domain containing 1
MSMO1 methylsterol monooxygenase 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
PLP1 proteolipid protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
TCTN1 tectonic family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ALCAM activated leukocyte cell adhesion molecule
CCL4 chemokine (C-C motif) ligand 4
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
ECI2 enoyl-CoA delta isomerase 2
FKBP5 FK506 binding protein 5
GIMAP4 GTPase, IMAP family member 4
IGKC immunoglobulin kappa constant
JCHAIN joining chain of multimeric IgA and IgM
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MME membrane metallo-endopeptidase
NRN1 neuritin 1
PALLD palladin, cytoskeletal associated protein
PLSCR3 phospholipid scramblase 3
PRKCH protein kinase C, eta
RCAN1 regulator of calcineurin 1
REXO2 RNA exonuclease 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX9 SRY (sex determining region Y)-box 9
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM9SF3 transmembrane 9 superfamily member 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
VDAC1 voltage-dependent anion channel 1
ZW10 zw10 kinetochore protein