BRD-K49448285_Bisindolylmaleimide IV_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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52 genes differentially expressed following the BRD-K49448285_Bisindolylmaleimide IV_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AREG amphiregulin
BHLHE40 basic helix-loop-helix family, member e40
CD24 CD24 molecule
CHMP6 charged multivesicular body protein 6
CLU clusterin
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
FAM117A family with sequence similarity 117, member A
FGFR4 fibroblast growth factor receptor 4
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
KLF4 Kruppel-like factor 4 (gut)
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRKCQ protein kinase C, theta
S100A8 S100 calcium binding protein A8
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPST1 tyrosylprotein sulfotransferase 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ATAD2 ATPase family, AAA domain containing 2
C1QB complement component 1, q subcomponent, B chain
CENPN centromere protein N
CFD complement factor D (adipsin)
CPE carboxypeptidase E
DCN decorin
DSTN destrin (actin depolymerizing factor)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
JCHAIN joining chain of multimeric IgA and IgM
KLK11 kallikrein-related peptidase 11
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MSMB microseminoprotein, beta-
NFIB nuclear factor I/B
OLFM4 olfactomedin 4
PFDN4 prefoldin subunit 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POSTN periostin, osteoblast specific factor
PRUNE2 prune homolog 2 (Drosophila)
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
SNX6 sorting nexin 6
TARP TCR gamma alternate reading frame protein
TBX2 T-box 2