BRD-K49448285_Bisindolylmaleimide IV_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K49448285_Bisindolylmaleimide IV_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AQP9 aquaporin 9
ASPN asporin
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP4 fatty acid binding protein 4, adipocyte
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GLUL glutamate-ammonia ligase
GPX7 glutathione peroxidase 7
GREM1 gremlin 1, DAN family BMP antagonist
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KLF2 Kruppel-like factor 2
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LOX lysyl oxidase
LPL lipoprotein lipase
METTL7A methyltransferase like 7A
MFAP2 microfibrillar-associated protein 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP11 matrix metallopeptidase 11
MT1X metallothionein 1X
NFIL3 nuclear factor, interleukin 3 regulated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCOLCE procollagen C-endopeptidase enhancer
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP2A RAP2A, member of RAS oncogene family
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB2 WD repeat and SOCS box containing 2

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
BLNK B-cell linker
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD99 CD99 molecule
COL4A6 collagen, type IV, alpha 6
DEFA5 defensin, alpha 5, Paneth cell-specific
ERBB2 erb-b2 receptor tyrosine kinase 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GPX3 glutathione peroxidase 3
HOXB6 homeobox B6
HOXB7 homeobox B7
JCHAIN joining chain of multimeric IgA and IgM
NLGN4X neuroligin 4, X-linked
NPTX2 neuronal pentraxin II
PGK1 phosphoglycerate kinase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB4 phospholipase C, beta 4
PRKCB protein kinase C, beta
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
TGFBR3 transforming growth factor, beta receptor III
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
VAV3 vav 3 guanine nucleotide exchange factor