BRD-K49448285_Bisindolylmaleimide IV_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K49448285_Bisindolylmaleimide IV_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACAA2 acetyl-CoA acyltransferase 2
ADGRL2 adhesion G protein-coupled receptor L2
ARG2 arginase 2
ASS1 argininosuccinate synthase 1
CA12 carbonic anhydrase XII
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CSNK1A1 casein kinase 1, alpha 1
FRMD4B FERM domain containing 4B
FRZB frizzled-related protein
FZD5 frizzled class receptor 5
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMG20B high mobility group 20B
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IGKV1-5 immunoglobulin kappa variable 1-5
IVNS1ABP influenza virus NS1A binding protein
KIZ kizuna centrosomal protein
KRT14 keratin 14, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NPTX2 neuronal pentraxin II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PKP2 plakophilin 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE4 ribonuclease, RNase A family, 4
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON2 spondin 2, extracellular matrix protein
THSD7A thrombospondin, type I, domain containing 7A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOX thymocyte selection-associated high mobility group box

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
ENO1 enolase 1, (alpha)
ETV1 ets variant 1
FAM3C family with sequence similarity 3, member C
FXYD3 FXYD domain containing ion transport regulator 3
HAL histidine ammonia-lyase
HSPA1A heat shock 70kDa protein 1A
IGFBP3 insulin-like growth factor binding protein 3
KDM3A lysine (K)-specific demethylase 3A
KRT7 keratin 7, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NRIP1 nuclear receptor interacting protein 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RRAGD Ras-related GTP binding D
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18