BRD-K49328571_dasatinib_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K49328571_dasatinib_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNG2 cyclin G2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFI complement factor I
CTSA cathepsin A
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
ETV1 ets variant 1
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GPC4 glypican 4
GPR137B G protein-coupled receptor 137B
GPX2 glutathione peroxidase 2
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTRA1 HtrA serine peptidase 1
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IQGAP2 IQ motif containing GTPase activating protein 2
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
KDM3A lysine (K)-specific demethylase 3A
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGK1 phosphoglycerate kinase 1
PROS1 protein S (alpha)
PTEN phosphatase and tensin homolog
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
YPEL5 yippee-like 5 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMD1 adenosylmethionine decarboxylase 1
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
AXL AXL receptor tyrosine kinase
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAR2 fatty acyl CoA reductase 2
FEN1 flap structure-specific endonuclease 1
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCH1 GTP cyclohydrolase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HMGB2 high mobility group box 2
IGF1 insulin-like growth factor 1 (somatomedin C)
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOTCH2 notch 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PCNA proliferating cell nuclear antigen
PEA15 phosphoprotein enriched in astrocytes 15
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC43A3 solute carrier family 43, member 3
SPP1 secreted phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TEAD4 TEA domain family member 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TPX2 TPX2, microtubule-associated
ZWINT ZW10 interacting kinetochore protein