BRD-K49328571_dasatinib_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K49328571_dasatinib_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
CD24 CD24 molecule
CLU clusterin
COCH cochlin
CRISP3 cysteine-rich secretory protein 3
CTAG2 cancer/testis antigen 2
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
FBLN5 fibulin 5
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
IER3 immediate early response 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ISG15 ISG15 ubiquitin-like modifier
ITGB5 integrin, beta 5
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LPP LIM domain containing preferred translocation partner in lipoma
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NCALD neurocalcin delta
NOV nephroblastoma overexpressed
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PRAME preferentially expressed antigen in melanoma
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SATB2 SATB homeobox 2
SCGB1D2 secretoglobin, family 1D, member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SETBP1 SET binding protein 1
SETD5 SET domain containing 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
TATDN2 TatD DNase domain containing 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I
TUSC3 tumor suppressor candidate 3
VDAC1 voltage-dependent anion channel 1
VLDLR very low density lipoprotein receptor
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ANPEP alanyl (membrane) aminopeptidase
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
COL5A2 collagen, type V, alpha 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUOX2 dual oxidase 2
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
F2R coagulation factor II (thrombin) receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGL2 fibrinogen-like 2
FNTA farnesyltransferase, CAAX box, alpha
FSTL1 follistatin-like 1
GTF2A2 general transcription factor IIA, 2, 12kDa
GTPBP8 GTP-binding protein 8 (putative)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOPX HOP homeobox
HOXB2 homeobox B2
IER5 immediate early response 5
JCHAIN joining chain of multimeric IgA and IgM
KLF10 Kruppel-like factor 10
LIMA1 LIM domain and actin binding 1
LPAR1 lysophosphatidic acid receptor 1
LRRC17 leucine rich repeat containing 17
MFAP5 microfibrillar associated protein 5
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG10 paternally expressed 10
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM9SF3 transmembrane 9 superfamily member 3
WBP5 WW domain binding protein 5