BRD-K49328571_dasatinib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K49328571_dasatinib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACACB acetyl-CoA carboxylase beta
ADGRG2 adhesion G protein-coupled receptor G2
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
CBR3 carbonyl reductase 3
CD3D CD3d molecule, delta (CD3-TCR complex)
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
DCN decorin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FBLN1 fibulin 1
FYB FYN binding protein
GAS1 growth arrest-specific 1
HES1 hes family bHLH transcription factor 1
IFNGR1 interferon gamma receptor 1
IQGAP2 IQ motif containing GTPase activating protein 2
ITK IL2-inducible T-cell kinase
ITM2A integral membrane protein 2A
JADE1 jade family PHD finger 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LUM lumican
MAGEA3 melanoma antigen family A3
MT1M metallothionein 1M
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCQ protein kinase C, theta
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX3 runt-related transcription factor 3
SCGB2A1 secretoglobin, family 2A, member 1
SLA Src-like-adaptor
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SYT1 synaptotagmin I
TMEM47 transmembrane protein 47
TNS1 tensin 1
TPBG trophoblast glycoprotein
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
VCAN versican
XYLT1 xylosyltransferase I
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CDCA4 cell division cycle associated 4
CHIC2 cysteine-rich hydrophobic domain 2
CNPY3 canopy FGF signaling regulator 3
CTSH cathepsin H
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUOX2 dual oxidase 2
EFNB2 ephrin-B2
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
FST follistatin
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
HMGA2 high mobility group AT-hook 2
INHBA inhibin, beta A
JUN jun proto-oncogene
P3H2 prolyl 3-hydroxylase 2
PDGFA platelet-derived growth factor alpha polypeptide
PLAU plasminogen activator, urokinase
PLEK2 pleckstrin 2
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFF1 trefoil factor 1
TNS3 tensin 3