BRD-K49328571_dasatinib_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K49328571_dasatinib_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
CBR3 carbonyl reductase 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHRDL1 chordin-like 1
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
ESR1 estrogen receptor 1
FGFR2 fibroblast growth factor receptor 2
GLUL glutamate-ammonia ligase
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
LAMP5 lysosomal-associated membrane protein family, member 5
LMO2 LIM domain only 2 (rhombotin-like 1)
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
MX2 MX dynamin-like GTPase 2
NFIL3 nuclear factor, interleukin 3 regulated
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRL platelet-derived growth factor receptor-like
PENK proenkephalin
PMP22 peripheral myelin protein 22
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTEN phosphatase and tensin homolog
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SESN1 sestrin 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYNM synemin, intermediate filament protein
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP11B ATPase, class VI, type 11B
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDK14 cyclin-dependent kinase 14
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CNN3 calponin 3, acidic
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IPO5 importin 5
JUN jun proto-oncogene
LYRM1 LYR motif containing 1
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
OSBPL3 oxysterol binding protein-like 3
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SAMD4A sterile alpha motif domain containing 4A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMYD2 SET and MYND domain containing 2
SNAI2 snail family zinc finger 2
SPP1 secreted phosphoprotein 1
SRSF11 serine/arginine-rich splicing factor 11
TFF1 trefoil factor 1
TFRC transferrin receptor
TNF tumor necrosis factor
TNS3 tensin 3
TPM4 tropomyosin 4
UFM1 ubiquitin-fold modifier 1