BRD-K49328571_dasatinib_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

275 genes differentially expressed following the BRD-K49328571_dasatinib_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
APOD apolipoprotein D
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CAPN1 calpain 1, (mu/I) large subunit
CCNA1 cyclin A1
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CHN1 chimerin 1
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA4 chloride channel accessory 4
CLDN10 claudin 10
CLDN7 claudin 7
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CTSD cathepsin D
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DEFB1 defensin, beta 1
DPT dermatopontin
DUSP22 dual specificity phosphatase 22
EGFL6 EGF-like-domain, multiple 6
EIF4B eukaryotic translation initiation factor 4B
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FAM65B family with sequence similarity 65, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FGF9 fibroblast growth factor 9
FGFR2 fibroblast growth factor receptor 2
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPB8 heat shock 22kDa protein 8
ICAM3 intercellular adhesion molecule 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFT27 intraflagellar transport 27
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ILVBL ilvB (bacterial acetolactate synthase)-like
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHFPL2 lipoma HMGIC fusion partner-like 2
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
LXN latexin
LYZ lysozyme
MAL mal, T-cell differentiation protein
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MSLN mesothelin
MUC1 mucin 1, cell surface associated
MVP major vault protein
MX2 MX dynamin-like GTPase 2
MXRA5 matrix-remodelling associated 5
NBEA neurobeachin
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAM peptidylglycine alpha-amidating monooxygenase
PCCB propionyl CoA carboxylase, beta polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PFKM phosphofructokinase, muscle
PGD phosphogluconate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNPLA4 patatin-like phospholipase domain containing 4
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPL periplakin
PRDX2 peroxiredoxin 2
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA2 surfactant protein A2
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON1 spondin 1, extracellular matrix protein
SPRR3 small proline-rich protein 3
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TFRC transferrin receptor
TM7SF2 transmembrane 7 superfamily member 2
TMOD1 tropomodulin 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VCAN versican
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC6 cell division cycle 6
CEP55 centrosomal protein 55kDa
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSV cathepsin V
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FST follistatin
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MXRA7 matrix-remodelling associated 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NRG1 neuregulin 1
PCDH9 protocadherin 9
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHACTR2 phosphatase and actin regulator 2
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
PTX3 pentraxin 3, long
REEP5 receptor accessory protein 5
RFC2 replication factor C (activator 1) 2, 40kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPP1 secreted phosphoprotein 1
TAGLN transgelin
TARP TCR gamma alternate reading frame protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein