BRD-K49328571_dasatinib_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K49328571_dasatinib_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASS1 argininosuccinate synthase 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BCL6 B-cell CLL/lymphoma 6
BPIFA1 BPI fold containing family A, member 1
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
C7 complement component 7
CA2 carbonic anhydrase II
CAPN1 calpain 1, (mu/I) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CFB complement factor B
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CLDN3 claudin 3
CLDN7 claudin 7
COL14A1 collagen, type XIV, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CTSD cathepsin D
CXCL13 chemokine (C-X-C motif) ligand 13
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
EPHA3 EPH receptor A3
FABP4 fatty acid binding protein 4, adipocyte
FAM65B family with sequence similarity 65, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FGF9 fibroblast growth factor 9
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GPM6B glycoprotein M6B
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ITGB4 integrin, beta 4
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC16A leucine rich repeat containing 16A
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
LYZ lysozyme
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MUC1 mucin 1, cell surface associated
MX2 MX dynamin-like GTPase 2
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH1 notch 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK2 polo-like kinase 2
PPL periplakin
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PRR15L proline rich 15-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPL31 ribosomal protein L31
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
VCAN versican
VNN1 vanin 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ANXA1 annexin A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CHMP6 charged multivesicular body protein 6
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DFNA5 deafness, autosomal dominant 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FOSL1 FOS-like antigen 1
FST follistatin
GINS1 GINS complex subunit 1 (Psf1 homolog)
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL32 interleukin 32
INHBA inhibin, beta A
LAMC2 laminin, gamma 2
MALL mal, T-cell differentiation protein-like
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO10 myosin X
NID2 nidogen 2 (osteonidogen)
NOP56 NOP56 ribonucleoprotein
NRG1 neuregulin 1
NSFL1C NSFL1 (p97) cofactor (p47)
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PTHLH parathyroid hormone-like hormone
PTRF polymerase I and transcript release factor
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPTBN1 spectrin, beta, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFC vascular endothelial growth factor C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)