BRD-K49328571_dasatinib_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

322 genes differentially expressed following the BRD-K49328571_dasatinib_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD2 abhydrolase domain containing 2
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMACR alpha-methylacyl-CoA racemase
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
ANXA4 annexin A4
ARHGAP32 Rho GTPase activating protein 32
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATP9A ATPase, class II, type 9A
AUTS2 autism susceptibility candidate 2
BAD BCL2-associated agonist of cell death
BASP1 brain abundant, membrane attached signal protein 1
BBS1 Bardet-Biedl syndrome 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CALML4 calmodulin-like 4
CAPN3 calpain 3, (p94)
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CCNG1 cyclin G1
CCNG2 cyclin G2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA1 chloride channel accessory 1
CLDN18 claudin 18
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSG cathepsin G
CTSH cathepsin H
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBXO11 F-box protein 11
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
HAL histidine ammonia-lyase
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT7 keratin 7, type II
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LXN latexin
LY75 lymphocyte antigen 75
MAOA monoamine oxidase A
MARCKSL1 MARCKS-like 1
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MTSS1 metastasis suppressor 1
MVP major vault protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PDZRN3 PDZ domain containing ring finger 3
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PFKL phosphofructokinase, liver
PHYH phytanoyl-CoA 2-hydroxylase
PLCB4 phospholipase C, beta 4
PNMA2 paraneoplastic Ma antigen 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB40B RAB40B, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN3 reticulon 3
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC44A4 solute carrier family 44, member 4
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SSR4 signal sequence receptor, delta
STAG3 stromal antigen 3
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TCEAL4 transcription elongation factor A (SII)-like 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TM9SF2 transmembrane 9 superfamily member 2
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TSPAN1 tetraspanin 1
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP22 ubiquitin specific peptidase 22
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ALB albumin
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
APOC1 apolipoprotein C-I
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
BARD1 BRCA1 associated RING domain 1
BIRC3 baculoviral IAP repeat containing 3
BLMH bleomycin hydrolase
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CD34 CD34 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLC Charcot-Leyden crystal galectin
CLGN calmegin
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COPS4 COP9 signalosome subunit 4
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CSTA cystatin A (stefin A)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DLX2 distal-less homeobox 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENDOD1 endonuclease domain containing 1
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLRX2 glutaredoxin 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTPBP8 GTP-binding protein 8 (putative)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
IRF1 interferon regulatory factor 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LPAR1 lysophosphatidic acid receptor 1
LPAR6 lysophosphatidic acid receptor 6
LSM1 LSM1, U6 small nuclear RNA associated
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MRPS16 mitochondrial ribosomal protein S16
MSH6 mutS homolog 6
MTERF3 mitochondrial transcription termination factor 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX2 neuronal pentraxin II
NRGN neurogranin (protein kinase C substrate, RC3)
ODC1 ornithine decarboxylase 1
PAWR PRKC, apoptosis, WT1, regulator
PDCD10 programmed cell death 10
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM1 PDZ and LIM domain 1
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF4 pre-mRNA processing factor 4
PXMP2 peroxisomal membrane protein 2, 22kDa
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBM34 RNA binding motif protein 34
RBP1 retinol binding protein 1, cellular
RDX radixin
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SCG2 secretogranin II
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLN sarcolipin
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRM spermidine synthase
TCTN1 tectonic family member 1
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM70 transmembrane protein 70
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRH thyrotropin-releasing hormone
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)