BRD-K49328571_dasatinib_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

309 genes differentially expressed following the BRD-K49328571_dasatinib_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM2 absent in melanoma 2
AKR1C3 aldo-keto reductase family 1, member C3
ANGPTL2 angiopoietin-like 2
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AREG amphiregulin
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BBX bobby sox homolog (Drosophila)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG2 BTG family, member 2
C5ORF30 chromosome 5 open reading frame 30
CCNG1 cyclin G1
CCNG2 cyclin G2
CDC14B cell division cycle 14B
CDC25B cell division cycle 25B
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
COX7C cytochrome c oxidase subunit VIIc
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CRABP1 cellular retinoic acid binding protein 1
CSF1R colony stimulating factor 1 receptor
CST1 cystatin SN
CST3 cystatin C
CTSA cathepsin A
DENND1B DENN/MADD domain containing 1B
DPP4 dipeptidyl-peptidase 4
DPT dermatopontin
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FAM13A family with sequence similarity 13, member A
FAM46A family with sequence similarity 46, member A
FAM63A family with sequence similarity 63, member A
FGFR2 fibroblast growth factor receptor 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXC1 forkhead box C1
FOXO4 forkhead box O4
FZD5 frizzled class receptor 5
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2AC histone cluster 1, H2ac
HMGN4 high mobility group nucleosomal binding domain 4
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXD1 homeobox D1
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IL7 interleukin 7
IRS1 insulin receptor substrate 1
ITM2B integral membrane protein 2B
ITM2C integral membrane protein 2C
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIZ kizuna centrosomal protein
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT20 keratin 20, type I
LAMP2 lysosomal-associated membrane protein 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NCALD neurocalcin delta
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
PAM peptidylglycine alpha-amidating monooxygenase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCLO piccolo presynaptic cytomatrix protein
PGAP1 post-GPI attachment to proteins 1
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS1 plastin 1
PPL periplakin
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RAP2A RAP2A, member of RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA2 replication protein A2, 32kDa
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SCGB1D2 secretoglobin, family 1D, member 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFXN3 sideroflexin 3
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SSFA2 sperm specific antigen 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
UST uronyl-2-sulfotransferase
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YPEL5 yippee-like 5 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ALCAM activated leukocyte cell adhesion molecule
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ARF1 ADP-ribosylation factor 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AXL AXL receptor tyrosine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD24 CD24 molecule
CD69 CD69 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CENPU centromere protein U
COL5A1 collagen, type V, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FILIP1L filamin A interacting protein 1-like
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GADD45B growth arrest and DNA-damage-inducible, beta
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
HAT1 histone acetyltransferase 1
HSPA2 heat shock 70kDa protein 2
IFRD2 interferon-related developmental regulator 2
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
INHBA inhibin, beta A
KLC1 kinesin light chain 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LBR lamin B receptor
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MRPS7 mitochondrial ribosomal protein S7
MSX1 msh homeobox 1
MYCBP MYC binding protein
NET1 neuroepithelial cell transforming 1
NUP85 nucleoporin 85kDa
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDAP1 PDGFA associated protein 1
PEX11A peroxisomal biogenesis factor 11 alpha
PGAP3 post-GPI attachment to proteins 3
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX1 peroxiredoxin 1
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
PSMC3IP PSMC3 interacting protein
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTRF polymerase I and transcript release factor
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SRSF1 serine/arginine-rich splicing factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK10 serine/threonine kinase 10
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TAGLN2 transgelin 2
TK1 thymidine kinase 1, soluble
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNNC1 troponin C type 1 (slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TRIP13 thyroid hormone receptor interactor 13
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC6 zinc finger, DHHC-type containing 6