BRD-K49328571_dasatinib_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K49328571_dasatinib_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANGPTL2 angiopoietin-like 2
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTG2 BTG family, member 2
BTN3A3 butyrophilin, subfamily 3, member A3
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25B cell division cycle 25B
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
COL14A1 collagen, type XIV, alpha 1
CP ceruloplasmin (ferroxidase)
CPVL carboxypeptidase, vitellogenic-like
CSF1R colony stimulating factor 1 receptor
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CTSB cathepsin B
CTSK cathepsin K
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPCAM epithelial cell adhesion molecule
ERP29 endoplasmic reticulum protein 29
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM13A family with sequence similarity 13, member A
FAM46A family with sequence similarity 46, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO4 forkhead box O4
GRN granulin
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LDB2 LIM domain binding 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100505650 uncharacterized LOC100505650
LPAR1 lysophosphatidic acid receptor 1
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LY75 lymphocyte antigen 75
LYN LYN proto-oncogene, Src family tyrosine kinase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAST4 microtubule associated serine/threonine kinase family member 4
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
N4BP2L1 NEDD4 binding protein 2-like 1
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NNT nicotinamide nucleotide transhydrogenase
NPY1R neuropeptide Y receptor Y1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHYH phytanoyl-CoA 2-hydroxylase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PLS1 plastin 1
PPAP2B phosphatidic acid phosphatase type 2B
PRDX2 peroxiredoxin 2
PROS1 protein S (alpha)
PSD3 pleckstrin and Sec7 domain containing 3
PTER phosphotriesterase related
PTN pleiotrophin
RAB29 RAB29, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE6 ribonuclease, RNase A family, k6
RNASET2 ribonuclease T2
RNF144A ring finger protein 144A
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SATB1 SATB homeobox 1
SATB2 SATB homeobox 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SYT1 synaptotagmin I
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM30B transmembrane protein 30B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
WWOX WW domain containing oxidoreductase
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF277 zinc finger protein 277
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ACTG2 actin, gamma 2, smooth muscle, enteric
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ARHGAP29 Rho GTPase activating protein 29
ATAD2 ATPase family, AAA domain containing 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLIC4 chloride intracellular channel 4
CNN1 calponin 1, basic, smooth muscle
COL5A1 collagen, type V, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTPS1 CTP synthase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFV H2A histone family, member V
IFRD2 interferon-related developmental regulator 2
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
LOX lysyl oxidase
LRRC59 leucine rich repeat containing 59
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MICALL1 MICAL-like 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRG1 neuregulin 1
PBX3 pre-B-cell leukemia homeobox 3
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRKCH protein kinase C, eta
PRSS23 protease, serine, 23
PSMC3IP PSMC3 interacting protein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SAMD4A sterile alpha motif domain containing 4A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHCBP1 SHC SH2-domain binding protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORBS1 sorbin and SH3 domain containing 1
SPP1 secreted phosphoprotein 1
STK10 serine/threonine kinase 10
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TMEM255A transmembrane protein 255A
TMEM47 transmembrane protein 47
TPM1 tropomyosin 1 (alpha)
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCK2 uridine-cytidine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZWINT ZW10 interacting kinetochore protein