BRD-K49328571_dasatinib_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K49328571_dasatinib_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AFF1 AF4/FMR2 family, member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
BAALC brain and acute leukemia, cytoplasmic
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPT1A carnitine palmitoyltransferase 1A (liver)
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
EFHD1 EF-hand domain family, member D1
ELOVL2 ELOVL fatty acid elongase 2
ETV1 ets variant 1
F2R coagulation factor II (thrombin) receptor
HOXA5 homeobox A5
HOXB7 homeobox B7
IDO1 indoleamine 2,3-dioxygenase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KDM3A lysine (K)-specific demethylase 3A
KRT15 keratin 15, type I
LAMB1 laminin, beta 1
MAOB monoamine oxidase B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MYOF myoferlin
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLIN2 perilipin 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS2 regulator of G-protein signaling 2
SAP30 Sin3A-associated protein, 30kDa
SIK1 salt-inducible kinase 1
SRGN serglycin
STOM stomatin
SYNM synemin, intermediate filament protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF4 transmembrane 4 L six family member 4
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AUTS2 autism susceptibility candidate 2
BMP2 bone morphogenetic protein 2
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CCNE2 cyclin E2
CD22 CD22 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
COL9A3 collagen, type IX, alpha 3
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP14 dual specificity phosphatase 14
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBN2 fibrillin 2
FGF13 fibroblast growth factor 13
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
ICAM1 intercellular adhesion molecule 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
JAG1 jagged 1
JUN jun proto-oncogene
KRT23 keratin 23, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP10 matrix metallopeptidase 10
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NEFL neurofilament, light polypeptide
NOP16 NOP16 nucleolar protein
PBX3 pre-B-cell leukemia homeobox 3
PI3 peptidase inhibitor 3, skin-derived
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBM34 RNA binding motif protein 34
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND3 Rho family GTPase 3
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFA transforming growth factor, alpha
UGDH UDP-glucose 6-dehydrogenase
VSNL1 visinin-like 1