BRD-K49328571_dasatinib_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K49328571_dasatinib_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
APOC1 apolipoprotein C-I
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASS1 argininosuccinate synthase 1
BCL6 B-cell CLL/lymphoma 6
BMP7 bone morphogenetic protein 7
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAT catalase
CD14 CD14 molecule
CD163 CD163 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CREG1 cellular repressor of E1A-stimulated genes 1
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
DDR1 discoidin domain receptor tyrosine kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
ECHDC2 enoyl CoA hydratase domain containing 2
ENGASE endo-beta-N-acetylglucosaminidase
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV1 ets variant 1
FAM13A family with sequence similarity 13, member A
FBLN1 fibulin 1
FBP1 fructose-1,6-bisphosphatase 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GAA glucosidase, alpha; acid
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS1 growth arrest-specific 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HBB hemoglobin, beta
HBD hemoglobin, delta
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BD histone cluster 1, H2bd
HK2 hexokinase 2
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HTRA1 HtrA serine peptidase 1
IFI30 interferon, gamma-inducible protein 30
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ISYNA1 inositol-3-phosphate synthase 1
JUNB jun B proto-oncogene
JUP junction plakoglobin
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
PER2 period circadian clock 2
PFKM phosphofructokinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RGS2 regulator of G-protein signaling 2
RNASET2 ribonuclease T2
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCAMP1 secretory carrier membrane protein 1
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPAG4 sperm associated antigen 4
SQSTM1 sequestosome 1
SSBP2 single-stranded DNA binding protein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CCK cholecystokinin
CCND1 cyclin D1
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
IL1B interleukin 1, beta
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NGRN neugrin, neurite outgrowth associated
NLRP2 NLR family, pyrin domain containing 2
NRG1 neuregulin 1
NUP85 nucleoporin 85kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PEA15 phosphoprotein enriched in astrocytes 15
PLAU plasminogen activator, urokinase
PRSS23 protease, serine, 23
PRSS3 protease, serine, 3
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORBS3 sorbin and SH3 domain containing 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein