BRD-K49328571_dasatinib_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

347 genes differentially expressed following the BRD-K49328571_dasatinib_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAA1 acetyl-CoA acyltransferase 1
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMDHD2 amidohydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP9A ATPase, class II, type 9A
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BEX1 brain expressed, X-linked 1
BPTF bromodomain PHD finger transcription factor
C1RL complement component 1, r subcomponent-like
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CALR calreticulin
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD8A CD8a molecule
CDK19 cyclin-dependent kinase 19
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL9A2 collagen, type IX, alpha 2
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPT1A carnitine palmitoyltransferase 1A (liver)
CRAT carnitine O-acetyltransferase
CRIP1 cysteine-rich protein 1 (intestinal)
CRYM crystallin, mu
CTSD cathepsin D
CXCL5 chemokine (C-X-C motif) ligand 5
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPP4 dipeptidyl-peptidase 4
EHF ets homologous factor
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENAH enabled homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FASN fatty acid synthase
FBN2 fibrillin 2
FGB fibrinogen beta chain
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GANAB glucosidase, alpha; neutral AB
GPX4 glutathione peroxidase 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM1 interferon induced transmembrane protein 1
IPO13 importin 13
IPW imprinted in Prader-Willi syndrome (non-protein coding)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM3A lysine (K)-specific demethylase 3A
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LINC00341 long intergenic non-protein coding RNA 341
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LY75 lymphocyte antigen 75
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPT microtubule-associated protein tau
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MPPED2 metallophosphoesterase domain containing 2
MSX1 msh homeobox 1
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MVP major vault protein
MYLK myosin light chain kinase
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NLGN4X neuroligin 4, X-linked
NNMT nicotinamide N-methyltransferase
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG3 paternally expressed 3
PKM pyruvate kinase, muscle
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PON2 paraoxonase 2
PRAME preferentially expressed antigen in melanoma
RAB40B RAB40B, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM47 RNA binding motif protein 47
RGS1 regulator of G-protein signaling 1
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SCAMP1 secretory carrier membrane protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC31A SEC31 homolog A (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLPI secretory leukocyte peptidase inhibitor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYT1 synaptotagmin I
TAPBP TAP binding protein (tapasin)
TBC1D16 TBC1 domain family, member 16
TCTA T-cell leukemia translocation altered
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TM7SF2 transmembrane 7 superfamily member 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TRAK2 trafficking protein, kinesin binding 2
TRIM16 tripartite motif containing 16
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
WASF1 WAS protein family, member 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRL2 adhesion G protein-coupled receptor L2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOE apolipoprotein E
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATF3 activating transcription factor 3
ATG3 autophagy related 3
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG3 BTG family, member 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD1E CD1e molecule
CD200 CD200 molecule
CDC42 cell division cycle 42
CDH10 cadherin 10, type 2 (T2-cadherin)
CENPU centromere protein U
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
CRYAB crystallin, alpha B
CSNK1A1 casein kinase 1, alpha 1
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL11 chemokine (C-X-C motif) ligand 11
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA4 defensin, alpha 4, corticostatin
DPYSL2 dihydropyrimidinase-like 2
DSG3 desmoglein 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR2 early growth response 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FERMT1 fermitin family member 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGL2 fibrinogen-like 2
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
GALC galactosylceramidase
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER5 immediate early response 5
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGKV1-5 immunoglobulin kappa variable 1-5
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
JAG1 jagged 1
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
KIF14 kinesin family member 14
LGALS1 lectin, galactoside-binding, soluble, 1
LIMA1 LIM domain and actin binding 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGLL monoglyceride lipase
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MRPL19 mitochondrial ribosomal protein L19
MRPS16 mitochondrial ribosomal protein S16
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NFE2L3 nuclear factor, erythroid 2-like 3
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OGFRL1 opioid growth factor receptor-like 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCDBP protein kinase C, delta binding protein
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSRC1 proline/serine-rich coiled-coil 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SAP30 Sin3A-associated protein, 30kDa
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD2 SET and MYND domain containing 2
SNAI2 snail family zinc finger 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
TAGLN transgelin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM123 transmembrane protein 123
TPM1 tropomyosin 1 (alpha)
TRBC1 T cell receptor beta constant 1
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
YME1L1 YME1-like 1 ATPase
ZNF395 zinc finger protein 395
ZWINT ZW10 interacting kinetochore protein