BRD-K49328571_dasatinib_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

450 genes differentially expressed following the BRD-K49328571_dasatinib_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANO1 anoctamin 1, calcium activated chloride channel
ANXA4 annexin A4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AREG amphiregulin
ARMCX2 armadillo repeat containing, X-linked 2
ASPN asporin
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BAD BCL2-associated agonist of cell death
BCL6 B-cell CLL/lymphoma 6
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
C14ORF132 chromosome 14 open reading frame 132
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNF cyclin F
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREG1 cellular repressor of E1A-stimulated genes 1
CRELD2 cysteine-rich with EGF-like domains 2
CREM cAMP responsive element modulator
CSRP1 cysteine and glycine-rich protein 1
CTSC cathepsin C
CTSH cathepsin H
CTSK cathepsin K
CXCL6 chemokine (C-X-C motif) ligand 6
CYBA cytochrome b-245, alpha polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
ECH1 enoyl CoA hydratase 1, peroxisomal
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ERAP1 endoplasmic reticulum aminopeptidase 1
ETFB electron-transfer-flavoprotein, beta polypeptide
ETV1 ets variant 1
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GLG1 golgi glycoprotein 1
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GSTZ1 glutathione S-transferase zeta 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST3H2A histone cluster 3, H2a
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HNMT histamine N-methyltransferase
HOOK2 hook microtubule-tethering protein 2
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5A lysine (K)-specific demethylase 5A
KRT17 keratin 17, type I
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MX1 MX dynamin-like GTPase 1
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
MYO5C myosin VC
N4BP2L2 NEDD4 binding protein 2-like 2
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID1 nidogen 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4DIP phosphodiesterase 4D interacting protein
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLD3 phospholipase D family, member 3
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROS1 protein S (alpha)
PRTN3 proteinase 3
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS27L ribosomal protein S27-like
RTN2 reticulon 2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCP2 sterol carrier protein 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRED2 sprouty-related, EVH1 domain containing 2
SPRR3 small proline-rich protein 3
SRPX sushi-repeat containing protein, X-linked
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCTN1 tectonic family member 1
TESC tescalcin
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TPR translocated promoter region, nuclear basket protein
TRIM22 tripartite motif containing 22
TUSC3 tumor suppressor candidate 3
TXN thioredoxin
TXNIP thioredoxin interacting protein
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VAMP8 vesicle-associated membrane protein 8
VDAC1 voltage-dependent anion channel 1
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)
XPO7 exportin 7
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACTC1 actin, alpha, cardiac muscle 1
ADAM12 ADAM metallopeptidase domain 12
ADAM19 ADAM metallopeptidase domain 19
ADCK3 aarF domain containing kinase 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADM adrenomedullin
AHNAK AHNAK nucleoprotein
AK4 adenylate kinase 4
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ANXA2 annexin A2
APOD apolipoprotein D
ARMCX6 armadillo repeat containing, X-linked 6
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD1E CD1e molecule
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK6 cyclin-dependent kinase 6
CDK8 cyclin-dependent kinase 8
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFLAR CASP8 and FADD-like apoptosis regulator
CHD7 chromodomain helicase DNA binding protein 7
CHPT1 choline phosphotransferase 1
CKB creatine kinase, brain
CLDN3 claudin 3
CLDN8 claudin 8
CLIC5 chloride intracellular channel 5
CNIH4 cornichon family AMPA receptor auxiliary protein 4
COCH cochlin
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CST1 cystatin SN
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI2 desumoylating isopeptidase 2
DHCR7 7-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EAPP E2F-associated phosphoprotein
EBP emopamil binding protein (sterol isomerase)
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB2 ephrin-B2
EGF epidermal growth factor
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXPH5 exophilin 5
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGL2 fibrinogen-like 2
FLNB filamin B, beta
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GLUD1 glutamate dehydrogenase 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HAPLN1 hyaluronan and proteoglycan link protein 1
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOMER2 homer scaffolding protein 2
HRASLS HRAS-like suppressor
HSPA13 heat shock protein 70kDa family, member 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
INHBA inhibin, beta A
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
IPO13 importin 13
IRF8 interferon regulatory factor 8
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
LY86 lymphocyte antigen 86
LYZ lysozyme
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MAPT microtubule-associated protein tau
MARS methionyl-tRNA synthetase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MOK MOK protein kinase
MRPS2 mitochondrial ribosomal protein S2
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYOF myoferlin
NCF2 neutrophil cytosolic factor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK7 NIMA-related kinase 7
NPR3 natriuretic peptide receptor 3
NRN1 neuritin 1
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
OXSR1 oxidative stress responsive 1
OXTR oxytocin receptor
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PEA15 phosphoprotein enriched in astrocytes 15
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR3 phospholipid scramblase 3
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
PRSS23 protease, serine, 23
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PYCR1 pyrroline-5-carboxylate reductase 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RCAN1 regulator of calcineurin 1
REEP5 receptor accessory protein 5
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RND3 Rho family GTPase 3
S100A10 S100 calcium binding protein A10
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SQLE squalene epoxidase
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STK10 serine/threonine kinase 10
STK17A serine/threonine kinase 17a
SUB1 SUB1 homolog (S. cerevisiae)
SYBU syntabulin (syntaxin-interacting)
TCF4 transcription factor 4
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TRAPPC3 trafficking protein particle complex 3
TRBC1 T cell receptor beta constant 1
TTC39A tetratricopeptide repeat domain 39A
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TWF2 twinfilin actin binding protein 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCK2 uridine-cytidine kinase 2
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase