BRD-K49328571_dasatinib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K49328571_dasatinib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AIM2 absent in melanoma 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA13 annexin A13
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZU1 azurocidin 1
BBX bobby sox homolog (Drosophila)
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CBR3 carbonyl reductase 3
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CERS6 ceramide synthase 6
CES1 carboxylesterase 1
CFB complement factor B
CFD complement factor D (adipsin)
CLGN calmegin
CLU clusterin
COG7 component of oligomeric golgi complex 7
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CTSD cathepsin D
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM46A family with sequence similarity 46, member A
FCGBP Fc fragment of IgG binding protein
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXF2 forkhead box F2
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GMDS GDP-mannose 4,6-dehydratase
GPC4 glypican 4
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HK1 hexokinase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
INHBB inhibin, beta B
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
KAZN kazrin, periplakin interacting protein
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0355 KIAA0355
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LAMB1 laminin, beta 1
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS8 lectin, galactoside-binding, soluble, 8
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPL lipoprotein lipase
LXN latexin
MAMLD1 mastermind-like domain containing 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYH11 myosin, heavy chain 11, smooth muscle
NDRG1 N-myc downstream regulated 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
OBSL1 obscurin-like 1
OLFML2A olfactomedin-like 2A
OSBPL10 oxysterol binding protein-like 10
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PROS1 protein S (alpha)
PRRC2C proline-rich coiled-coil 2C
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RNASE4 ribonuclease, RNase A family, 4
RNF144A ring finger protein 144A
RRAGD Ras-related GTP binding D
RRBP1 ribosome binding protein 1
RSAD2 radical S-adenosyl methionine domain containing 2
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SF1 splicing factor 1
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STC1 stanniocalcin 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM4SF20 transmembrane 4 L six family member 20
TM4SF4 transmembrane 4 L six family member 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VDAC1 voltage-dependent anion channel 1
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIRC3 baculoviral IAP repeat containing 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL13A1 collagen, type XIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL6A3 collagen, type VI, alpha 3
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DENND2D DENN/MADD domain containing 2D
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSE dermatan sulfate epimerase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD2 EF-hand domain family, member D2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FBN2 fibrillin 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GPER1 G protein-coupled estrogen receptor 1
GRAMD3 GRAM domain containing 3
GREM1 gremlin 1, DAN family BMP antagonist
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
IL1R2 interleukin 1 receptor, type II
ITM2A integral membrane protein 2A
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LRRC17 leucine rich repeat containing 17
MAGEB2 melanoma antigen family B2
MAPK13 mitogen-activated protein kinase 13
MGP matrix Gla protein
MICB MHC class I polypeptide-related sequence B
MMP12 matrix metallopeptidase 12
MYLK myosin light chain kinase
NCK2 NCK adaptor protein 2
NDP Norrie disease (pseudoglioma)
NT5DC2 5'-nucleotidase domain containing 2
ODC1 ornithine decarboxylase 1
OSBPL3 oxysterol binding protein-like 3
PCNA proliferating cell nuclear antigen
PEA15 phosphoprotein enriched in astrocytes 15
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
RAB4A RAB4A, member RAS oncogene family
RAI14 retinoic acid induced 14
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
SCG5 secretogranin V
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATS2L spermatogenesis associated, serine-rich 2-like
STAR steroidogenic acute regulatory protein
STK17A serine/threonine kinase 17a
TAGLN transgelin
TAGLN2 transgelin 2
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM6SF1 transmembrane 6 superfamily member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TSPAN5 tetraspanin 5
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
USP6NL USP6 N-terminal like
WNT5A wingless-type MMTV integration site family, member 5A