BRD-K49094915_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K49094915_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
CD163 CD163 molecule
CD200 CD200 molecule
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
DDIT4 DNA-damage-inducible transcript 4
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
FABP7 fatty acid binding protein 7, brain
FBXL12 F-box and leucine-rich repeat protein 12
GLUL glutamate-ammonia ligase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0753 KIAA0753
LOX lysyl oxidase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MXI1 MAX interactor 1, dimerization protein
NPTX2 neuronal pentraxin II
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PNMA2 paraneoplastic Ma antigen 2
PTN pleiotrophin
RIMS3 regulating synaptic membrane exocytosis 3
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
TCF4 transcription factor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VSIG4 V-set and immunoglobulin domain containing 4
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
BASP1 brain abundant, membrane attached signal protein 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CPB1 carboxypeptidase B1 (tissue)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
F5 coagulation factor V (proaccelerin, labile factor)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
H2AFV H2A histone family, member V
HEG1 heart development protein with EGF-like domains 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
ICAM2 intercellular adhesion molecule 2
IL17RB interleukin 17 receptor B
KIF14 kinesin family member 14
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MGAM maltase-glucoamylase
PDLIM1 PDZ and LIM domain 1
PDZD8 PDZ domain containing 8
PLA1A phospholipase A1 member A
PPIH peptidylprolyl isomerase H (cyclophilin H)
S100P S100 calcium binding protein P
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
TBC1D4 TBC1 domain family, member 4
TSPYL5 TSPY-like 5
UQCRH ubiquinol-cytochrome c reductase hinge protein