BRD-K49094915_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K49094915_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
AK4 adenylate kinase 4
ANOS1 anosmin 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CA9 carbonic anhydrase IX
CCND2 cyclin D2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLU clusterin
CP ceruloplasmin (ferroxidase)
DDIT4 DNA-damage-inducible transcript 4
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPN2 epsin 2
FAM162A family with sequence similarity 162, member A
GPI glucose-6-phosphate isomerase
GPM6A glycoprotein M6A
HILPDA hypoxia inducible lipid droplet-associated
HK1 hexokinase 1
HK2 hexokinase 2
KDM3A lysine (K)-specific demethylase 3A
KRT5 keratin 5, type II
LGALS8 lectin, galactoside-binding, soluble, 8
MMP12 matrix metallopeptidase 12
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZD2 PDZ domain containing 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PKM pyruvate kinase, muscle
RALGDS ral guanine nucleotide dissociation stimulator
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALDOB aldolase B, fructose-bisphosphate
AREG amphiregulin
CD93 CD93 molecule
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EREG epiregulin
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
HOXC6 homeobox C6
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
MOK MOK protein kinase
NUP85 nucleoporin 85kDa
OLFML2B olfactomedin-like 2B
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)