BRD-K49075727_nintedanib_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K49075727_nintedanib_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AMDHD2 amidohydrolase domain containing 2
CA2 carbonic anhydrase II
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
E2F2 E2F transcription factor 2
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0355 KIAA0355
MAB21L2 mab-21-like 2 (C. elegans)
MAL mal, T-cell differentiation protein
MVP major vault protein
PODXL podocalyxin-like
PTPRK protein tyrosine phosphatase, receptor type, K
PUF60 poly-U binding splicing factor 60KDa
RAB29 RAB29, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOCS2 suppressor of cytokine signaling 2
SPON1 spondin 1, extracellular matrix protein
SYNM synemin, intermediate filament protein
TOB1 transducer of ERBB2, 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARMCX2 armadillo repeat containing, X-linked 2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
CNN3 calponin 3, acidic
COL6A1 collagen, type VI, alpha 1
CTGF connective tissue growth factor
CTSH cathepsin H
CTSW cathepsin W
CYR61 cysteine-rich, angiogenic inducer, 61
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBLN1 fibulin 1
G0S2 G0/G1 switch 2
GRWD1 glutamate-rich WD repeat containing 1
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IL13RA2 interleukin 13 receptor, alpha 2
LRRC17 leucine rich repeat containing 17
MET MET proto-oncogene, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
PFN2 profilin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RHOB ras homolog family member B
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SNAP25 synaptosomal-associated protein, 25kDa
SPEN spen family transcriptional repressor