BRD-K49075727_nintedanib_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K49075727_nintedanib_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALR calreticulin
CD24 CD24 molecule
CD81 CD81 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFB complement factor B
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CTSG cathepsin G
CXCL2 chemokine (C-X-C motif) ligand 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GLRX glutaredoxin (thioltransferase)
GSAP gamma-secretase activating protein
IRS2 insulin receptor substrate 2
KCTD14 potassium channel tetramerization domain containing 14
KIAA1033 KIAA1033
KRT81 keratin 81, type II
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSN moesin
MT1H metallothionein 1H
NUCB2 nucleobindin 2
PLAU plasminogen activator, urokinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNMA2 paraneoplastic Ma antigen 2
PON2 paraoxonase 2
PRAF2 PRA1 domain family, member 2
PROCR protein C receptor, endothelial
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SC5D sterol-C5-desaturase
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SOCS2 suppressor of cytokine signaling 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMC5 transmembrane channel-like 5
TUBA1A tubulin, alpha 1a
VIM vimentin
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCNA2 cyclin A2
CDC45 cell division cycle 45
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSP desmoplakin
EGR2 early growth response 2
FGFR3 fibroblast growth factor receptor 3
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
IGFBP5 insulin-like growth factor binding protein 5
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
LHX2 LIM homeobox 2
LYZ lysozyme
MAL mal, T-cell differentiation protein
MOXD1 monooxygenase, DBH-like 1
PCNA proliferating cell nuclear antigen
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100P S100 calcium binding protein P
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
STC2 stanniocalcin 2
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
UBE2S ubiquitin-conjugating enzyme E2S
VCAM1 vascular cell adhesion molecule 1