BRD-K49075727_nintedanib_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K49075727_nintedanib_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
CD36 CD36 molecule (thrombospondin receptor)
CDH3 cadherin 3, type 1, P-cadherin (placental)
COCH cochlin
CPA3 carboxypeptidase A3 (mast cell)
CPVL carboxypeptidase, vitellogenic-like
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
HBB hemoglobin, beta
HOXC6 homeobox C6
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KIAA0922 KIAA0922
MAOB monoamine oxidase B
MATN2 matrilin 2
MTUS1 microtubule associated tumor suppressor 1
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
SDC2 syndecan 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THAP11 THAP domain containing 11
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB6 tubulin, beta 6 class V
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
AREG amphiregulin
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EPHA2 EPH receptor A2
EREG epiregulin
FOSL1 FOS-like antigen 1
FST follistatin
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
INHBA inhibin, beta A
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NGRN neugrin, neurite outgrowth associated
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMM2 phosphomannomutase 2
RAD51C RAD51 paralog C
RCAN1 regulator of calcineurin 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPEN spen family transcriptional repressor
SPINK1 serine peptidase inhibitor, Kazal type 1
TGFA transforming growth factor, alpha
TLR4 toll-like receptor 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
XPO7 exportin 7